Acta Pharmacologica Sinica

Structure genomics of SARS-CoV-2 and its Omicron variant

Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy

Zhi-feng Zou
Lei Yang
Zhi-ai Xu

Article 12 April 2024

Featured

Notoginsenoside R1 promotes Lgr5⁺ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling

Zhi-lun Yu
Rui-yang Gao
Wei Dou
ArticleOpen Access15 Mar 2024
Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2

Fan-le Zeng
Yuan Zhang
Cheng Huang
Article08 Apr 2024
A novel bispecific antibody drug conjugate targeting HER2 and HER3 with potent therapeutic efficacy against breast cancer

Hui-fang Zong
Xi Li
Jian-wei Zhu
Article11 Apr 2024
HBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis

Ya-juan Guo
Jing-jing Yao
Lin-lin Lu
ArticleOpen Access11 Mar 2024

Current issue

Structural and functional insights into the epigenetic regulator MRG15

Nan Jiang
Yong-bo Li
Xiu-ling Zhi
Review Article08 Jan 2024
Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression

Xiao-yu Ma
Man-man Chen
Ling-hua Meng
Review Article04 Jan 2024
Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates Aβ pathology in Alzheimer’s disease models

Xin-jie Guan
Zhi-qiang Deng
Min Li
Article15 Jan 2024
Chronic vascular pathogenesis results in the reduced serum Metrnl levels in ischemic stroke patients

Zhu-wei Miao
Nuo Wang
Chao-yu Miao
Article22 Jan 2024
Desloratadine alleviates ALS-like pathology in hSOD1^G93A mice via targeting 5HTR_2A on activated spinal astrocytes

Jian Lu
An-xu He
Xu Shen
Article29 Jan 2024
Glutamatergic neurons in ventral pallidum modulate heroin addiction via epithalamic innervation in rats

Ruo-song Chen
Jing Liu
Zhi-qiang Liu
Article07 Feb 2024

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Announcements

JOIN US | Deputy Director Position of SKLDR

State Key Laboratory of Drug Research (SKLDR), which was approved by Chinese Academy of Sciences under the unremitting efforts of reorganizing the state key laboratory system, is recruiting a Deputy Director. The candidate is expected to help SKLDR to continuously improve the academic influence and the ability to transform new drug achievements into real productivity.

Browse articles

Sodium oligomannate activates the enteroendocrine-vagal afferent pathways in APP/PS1 mice

Hua-shan Gong
Jing-pei Pan
Wei-fang Rong
Article03 May 2024
Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin E₂ in the lateral parabrachial nucleus of male rats

Jian-hui Xu
Tian-hui He
Jie Zhang
Article03 May 2024
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer

Xi-shan Wu
Xiao-yu Luo
Yan Zhang
Article02 May 2024
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol

Zhi-hua Zheng
Jiao-jiao Wang
Zhi-ping Liu
Article30 Apr 2024
Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis

Ana Beatriz Santos
Andreia Carona
Joana Bicker
Review Article29 Apr 2024
Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis

Jian-qin Lai
Le-le Zhao
Qi Qi
Article29 Apr 2024
Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages

Mo-ting Liu
Yao Zhang
Wei Tang
Article29 Apr 2024
Insomnia-related rodent models in drug discovery

Ze-ka Chen
Yuan-yuan Liu
Zhi-li Huang
Review Article26 Apr 2024
Endothelial deubiquinatase YOD1 mediates Ang II-induced vascular endothelial-mesenchymal transition and remodeling by regulating β-catenin

Wan-te Lin
Yu-cheng Jiang
Guang Liang
Article19 Apr 2024

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Assistant, Associate, or Full Professor

Athens, Georgia

University of Georgia
Associate Professor - Synthetic Biology

Position Summary We seek an Associate Professor in the department of Synthetic Biology (jcvi.org/research/synthetic-biology). We invite applicatio...

Rockville, Maryland

J. Craig Venter Institute
Associate or Senior Editor (microbial genetics, evolution, and epidemiology) Nature Communications

Job Title: Associate or Senior Editor (microbial genetics, evolution, and epidemiology), Nature Communications Locations: London, New York, Philade...

New York (US)

Springer Nature Ltd
Postdoctoral Research Fellow

Two postdoctoral positions offered at HMS to study the role hypothalamic leptin resistance in control of neuron activity

Boston, Massachusetts (US)

Boston Children’s Hospital-Ozcan Lab
Two Junior Research Group Leaders (f/d/m) for Photonics

Friedrich Schiller University is a traditional University with a strong research profile based in the heart of Germany. As a University covering al...

07743, Jena (DE)

Friedrich-Schiller-Universität Jena

This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.

Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy

Featured

Notoginsenoside R1 promotes Lgr5⁺ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling

Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2

A novel bispecific antibody drug conjugate targeting HER2 and HER3 with potent therapeutic efficacy against breast cancer

HBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis

Current issue

Structural and functional insights into the epigenetic regulator MRG15

Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression

Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates Aβ pathology in Alzheimer’s disease models

Chronic vascular pathogenesis results in the reduced serum Metrnl levels in ischemic stroke patients

Desloratadine alleviates ALS-like pathology in hSOD1^G93A mice via targeting 5HTR_2A on activated spinal astrocytes

Glutamatergic neurons in ventral pallidum modulate heroin addiction via epithalamic innervation in rats

Announcements

JOIN US | Deputy Director Position of SKLDR

Browse articles

Sodium oligomannate activates the enteroendocrine-vagal afferent pathways in APP/PS1 mice

Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin E₂ in the lateral parabrachial nucleus of male rats

Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer

Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol

Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis

Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis

Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages

Insomnia-related rodent models in drug discovery

Endothelial deubiquinatase YOD1 mediates Ang II-induced vascular endothelial-mesenchymal transition and remodeling by regulating β-catenin

Trending - Altmetric

Science jobs

Assistant, Associate, or Full Professor

Associate Professor - Synthetic Biology

Associate or Senior Editor (microbial genetics, evolution, and epidemiology) Nature Communications

Postdoctoral Research Fellow

Two Junior Research Group Leaders (f/d/m) for Photonics

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Characteristics of human infection with avian influenza viruses and development of new antiviral agents

Population pharmacokinetic modeling and simulation of huperzine A in elderly Chinese subjects

Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells

Chemotherapy-induced metastasis: molecular mechanisms and clinical therapies

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