Abstract
OBJECTIVE: : To examine the associations between leptin levels and body mass index (BMI), fat distribution (reflected by waist to hip ratio and skinfold measurements), and blood pressure in a rural Chinese population.
DESIGN AND SUBJECTS: A cross-sectional study of 294 participants who provided blood samples.
MEASUREMENTS: Plasma concentrations of leptin, BMI, waist to hip ratio, skinfold thickness, and blood pressure.
RESULTS: The average leptin concentration was 5.2 µg/l (3.1 for men and 7.3 for women). In univariate analyses, leptin levels were significantly correlated with BMI (r=0.47), abdominal skinfold thickness (r=0.53), triceps skinfold thickness (r=0.56), waist circumference (r=0.41), hip circumference (r=0.51), waist to hip ratio (r=0.17), and diastolic blood pressure (r=0.13). In multivariate analyses controlling for age, sex, education, current smoking, and alcohol use, independent associations between leptin levels and BMI, waist to hip ratio, waist circumference, and abdominal skinfold thickness remained. However, the significant association between leptin and blood pressure disappeared after adjusting for BMI, whereas the association between BMI and blood pressure persisted after adjusting for leptin level.
CONCLUSIONS: We observed a strong positive relationship between overall adiposity and leptin levels in both men and women in a rural Chinese population. In addition, leptin concentrations were significantly associated with central obesity measured by waist to hip ratio and abdominal skinfold, independent of overall obesity. The observed positive association between leptin and blood pressure was largely explained by BMI.
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References
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM . Positional cloning of the mouse obese gene and its human homologue Nature 1994 372: 425–432.
Bray GA . Leptin and leptomania Lancet 1996 348: 140–141.
Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P . Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks Science 1995 269: 546–549.
Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS . Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action Nature Med 1995 1: 1311–1314.
Considine RV, Caro JF . Leptin in humans: current progress and future directions Clin Chem 1996 42: 843–844.
Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF . Serum immunoreactive-leptin concentrations in normal-weight and obese humans New Engl J Med 1996 334: 292–295.
Arch JRS, Stock MJ, Trayhurn P . Leptin resistance in obese humans: does it exist and what does it mean? Int J Obes Relat Metab Disord 1998 22: 1159–1163.
Ostlund REJ, Yang JW, Klein S, Gingerich R . Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates J Clin Endocrinol Metab 1996 81: 3909–3913.
Guven S, El-Bershawi A, Sonnenberg GE, Wilson CR, Hoffmann RG . Plasma leptin and insulin levels in weight-reduced obese women with normal body mass index: relationships with body composition and insulin Diabetes 1999 48: 347–352.
Haffner SM, Gingerich RL, Miettinen H, Stern MP . Leptin concentration in relation to overall adiposity and regional body fat distribution in Mexican Americans Int J Obes Relat Metab Disord 1996 20: 904–908.
Zimmet P, Hodge A, Nicolson M, Staten M, de Courten M, Moore J, Morawiecki A, Lubina J, Collier G, Alberti G, Dowse G . Serum leptin concentration, obesity, and insulin resistance in Western Somoans: cross sectional study BMJ 1996 313: 965–969.
Luke AH, Rotimi CN, Cooper RS, Long AE, Forrester TE, Wilks R, Bennett FI, Ogunbiyi O, Compton JA, Bowsher RR . Leptin and body composition of Negerians, Jamaicans, and US blacks Am J Clin Nutr 1998 67: 391–396.
Ellis KJ, Nicolson M . Leptin levels and body fatness in children: effects of gender, ethnicity, and sexual development Pediatric Research 1997 42: 484–488.
Bennett FI, McFarlane-Anderson N, Wilks R, Luke A, Cooper RS, Forrester TE . Leptin concentration in women is influenced by regional distribution of adipose tissue Am J Clin Nutr 1997 66: 1340–1344.
Haynes WG, Sivitz WI, Morgan DA, Walsh SA, Mark AL . Sympathetic and cardiorenal actions of leptin Hypertension 1997 30: 619–623.
Shek EW, Brands MW, Hall JE . Chronic leptin infusion increase arterial pressure Hypertension 1998 31: 409–414.
Xu X, Niu T, Christiani DC, Weiss ST, Zhou Y, Chen C, Yang J, Fang Z, Jiang Z, Liang W, Zhang F . Environmental and occupational determinants of blood pressure in rural communities in China Ann Epidemiol 1997 7: 95–106.
Wang X, Wang B, Chen C, Yang J, Fang Z, Zuckerman B, Xu X . Familial aggregation of blood pressure in a rural Chinese community Am J Epidemiol 1999 149: 412–420.
National Institute of Health . Data preview from the People's Republic of China: data from USA-PRC Collaborative Study of Cardiovascular and Cardiopulmonary Epidemiology United States Department of Health and Human Services: Bethesda, MD 1989.
Ma Z, Gingerich RL, Santiago JV, Klein S, Smith CH, Landt M . Radioimmunoassay of leptin in human plasma Clin Chem 1996 42: 942–946.
SAS Institute Inc . SAS Procedures Guide, Version 6.11 Cary, NC: SAS Institute Inc. 1996.
Haffner SM, Mykkanen L, Stern MP . Leptin concentrations in women in the San Antonio Heart Study: effect of menopausal status and postmenopausal hormone repalcement therapy Am J Epidemiol 1997 146: 581–585.
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We would like to thank Dr Walter Willett for his helpful comments on this paper.
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Hu, F., Chen, C., Wang, B. et al. Leptin concentrations in relation to overall adiposity, fat distribution, and blood pressure in a rural Chinese population. Int J Obes 25, 121–125 (2001). https://doi.org/10.1038/sj.ijo.0801480
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DOI: https://doi.org/10.1038/sj.ijo.0801480
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