Abstract
Tamoxifen is a nonsteroidal anti-estrogenic drug used for adjuvant treatment of breast cancer and recently as a chemopreventative agent for breast cancer and, on an investigational basis, for other cancers. To date there are case reports of hypertriglyceridemia and fatty liver disease in tamoxifen users. Fatty liver is associated with visceral obesity and other components of the metabolic syndrome. Here we evaluated steatosis and adipose tissue distribution by CT scan in a cross-sectional study of 32 women on tamoxifen and 39 control women. Tamoxifen users had more visceral adipose tissue (VAT) and more liver fat than controls. This is the first study to demonstrate that fatty liver and intra-abdominal fat accumulation are common in breast cancer patients receiving tamoxifen. Prospective studies of tamoxifen should monitor metabolic changes in obese women with or without breast cancer.
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References
Osborne CK . Tamoxifen in the treatment of breast cancer New Engl J Med 1998 339: 1609–1618.
Noguchi M, Taniya T, Tajiri K, Nakano Y, Kitabayashi K, Miyazaki I, Koshino Y, Mabuchi H . Fatal hyperlipemia in a case of metastatic breast cancer treated by tamoxifen Br J Surg 1987 74: 586–587.
Kanel KT, Wolmark N, Thompson PD . Delayed severe triglyceridemia from tamoxifen New Engl J Med 1997 337: 281.
Ching CK, Smith PG, Long RG . Tamoxifen-associated hepatocellular damage and agranulocytosis Lancet 1992 339: 940.
Pinto HC, Baptista A, Camilo ME, Bruno de Costa E, Valente A, Carneiro de Moura M . Tamoxifen-associated steatohepatitis—report of three cases J Hepatol 1995 23: 95–97.
Gordon DH, Banerji MA, Wait R, Kral JG . Fatty livers in breast carcinoma patients on tamoxifen Am J Roentgen 1996 166: 40.
Ogawa Y, Murata Y, Nishioka A, Inomata T, Yoshida S . Tamoxifen-induced fatty liver in patients with breast cancer Lancet 1998 351: 725.
Kral JG, Schaffner F, Pierson RN Jr, Wang J . Body fat topography as an independent predictor of fatty liver Metabolism 1993 42: 548–551.
Marceau P, Biron S, Hould FS, Marceau S, Simard S, Thung SN, Kral JG . Liver pathology and the metabolic syndrome X in severe obesity J Clin Endocrinol Metab 1999 84: 1513–1517.
Love RR, Newcomb PA, Wiebe DA, Surawicz TS, Jordan VC, Carbone PP, Demets DL . Effects of tamoxifen therapy on lipid and lipoprotein levels in postmenopausal patients with node-negative breast cancer J Natl Cancer Inst 1990 82: 1327–1332.
Thangaraju M, Kumar K, Gandhirajan R, Sachdanandam P . Effect of tamoxifen on plasma lipids and lipoproteins in postmenopausal women with breast cancer Cancer 1994 74: 659–663.
Ballard-Barbash R, Schatzkin A, Carter CL, Kannel WB, Kreger BE, D'Agostino RB, Splansky G, Anderson KM, Helsel WE . Body fat distribution and breast cancer in the Framingham Study J Natl Cancer Inst 1990 82: 286–290.
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Nguyen, M., Stewart, R., Banerji, M. et al. Relationships between tamoxifen use, liver fat and body fat distribution in women with breast cancer. Int J Obes 25, 296–298 (2001). https://doi.org/10.1038/sj.ijo.0801488
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DOI: https://doi.org/10.1038/sj.ijo.0801488
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