Abstract
The effects of alcohol intake on haemodynamics and heart rate variability were investigated with relation to genotypes of aldehyde dehydrogenase 2 (ALDH2), which were determined in 33 male Japanese volunteers (mean ± s.e., 35.7 ± 1.4 years) using the PCR-RFLP method. On the alcohol intake day, they consumed 660 ml of beer containing 33 ml of ethanol (0.3–0.5 g/kg of body weight) from 18.00 to 18.30. On the control day, they ingested the same amount of non-alcoholic beer. Ambulatory blood pressure, heart rate, and ECG R-R intervals were measured during a 24-h period with a portable recorder. A power spectral analysis of R-R intervals was performed to obtain the low-frequency (LF) and high-frequency (HF) components. Sixteen subjects were homozygotes for the normal ALDH gene (active ALDH2), only one was a homozygote for the mutant ALDH2 gene (inactive ALDH2), and the remaining 16 were heterozygotes (inactive ALDH2). Alcohol intake did not change 24-h average blood pressure (BP) either in the active ALDH2 group or in the inactive ALDH2 group. However, during the time interval from 18.30 to 0.00, alcohol intake significantly decreased diastolic BP in the active ALDH2 group and both systolic and diastolic BPs in the inactive ALDH2 group. In the active ALDH2 group, alcohol intake did not change heart rate, while in the inactive ALDH2 group, alcohol intake significantly increased 24-h average heart rate by 5.3 ± 1.6 beats per minute (P < 0.01). In the active ALDH2 group, neither the LF nor the HF component was changed by alcohol intake, while in the inactive ALDH2 group, both the LF and the HF components were significantly decreased during the time interval from 18.30 to 0.00. These results demonstrate for the first time that ALDH2 genotypes modify the effects of intake of a small amount of alcohol on haemodynamics and heart rate variability in Japanese men.
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References
Potter JF, Beevers DG . Factors determining the acute pressor response to alcohol Clin Exp Hypertens [A] 1991; 13: 13–34
Reed TE, Hanna JM . Similarities and differences in acute cardiovascular responses to alcohol among normal men of European, Japanese, and Chinese ancestry: a univariate and multivariate analysis Alcohol Clin Exp Res 1986; 10: 560–563
Kupari M, Eriksson CJ, Heikkila J, Ylikahri R . Alcohol and the heart. Intense hemodynamic changes associated with alcohol flush in orientals Acta Med Scand 1983; 213: 91–98
Harada S, Misawa S, Agarwal DP, Goedde HW . Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese: isozyme variation and its possible role in alcohol intoxication Am J Hum Genet 1980; 32: 8–15
Suzuki K, Uchida A, Mizoi Y, Fukunaga T . A study on ADH2 and ALDH2 genotyping by PCR-RFLP and SSCP analyses with description of allele and genotype frequencies in Japanese, Finn and Lapp populations Alcohol Alcohol 1994; 29 (Suppl 1): 21–27
Harada S, Zhang S . New strategy for detection of ALDH2 mutant Alcohol Alcohol Suppl 1993; 1A: 11–13
Minami J, Kawano Y, Ishimitsu T, Takishita S . Blunted parasympathetic modulation in salt-sensitivepatients with essential hypertension: evaluation by power-spectral analysis of heart-rate variability J Hypertens 1997; 15: 727–735
Minami J, Ishimitsu T, Matsuoka H . Effects of smoking cessation on blood pressure and heart rate variability in habitual smokers Hypertension 1999; 33: 586–590
Tochikubo O, Ikeda A, Miyajima E, Ishii M . Effects of insufficient sleep on blood pressure monitored by a new multibiomedical recorder Hypertension 1996; 27: 1318–1324
Shibuya A, Yoshida A . Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver diseases: a strong association of the usual Caucasian-type aldehyde dehydrogenase gene (ALDH1(2)) with the disease Am J Hum Genet 1988; 43: 744–748
Kawano Y et al. Acute depressor effect of alcohol inpatients with essential hypertension Hypertension 1992; 20: 219–226
Rosito GA, Fuchs FD, Duncan BB . Dose-dependent biphasic effect of ethanol on 24-h blood pressure in normotensive subjects Am J Hypertens 1999; 12: 236–240
Altura BM, Carella A, Altura BT . Acetaldehyde on vascular smooth muscle: possible role in vasodilator action of ethanol Eur J Pharmacol 1978; 52: 73–83
Thevananther S, Brecher AS . Acetaldehyde inhibits angiotensin-converting enzyme activity of bovine lung Alcohol 1993; 10: 545–548
Hatake K et al. Possible involvement of kinins in cardiovascular changes after alcohol intake Pharmacol Biochem Behav 1990; 35: 437–442
Mizoi Y et al. Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism Alcohol Alcohol 1994; 29: 707–710
No authors listed. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology Circulation 1996; 93: 1043–1065
Tsuji H et al. Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study Circulation 1996; 94: 2850–2855
Acknowledgements
We wish to thank Nobuo Shirahashi, PhD, Novartis Pharma Co, Ltd., Osaka, Japan, for assisting us in the statistical analysis. We also acknowledge J David Sinclair, PhD, Department of Mental Health and Alcohol Research, National Public Health Institute (KTL), Helsinki, Finland, for careful review of the manuscript. This work was supported by the grant of the All Japan Coffee Association.
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Minami, J., Todoroki, M., Ishimitsu, T. et al. Effects of alcohol intake on ambulatory blood pressure, heart rate, and heart rate variability in Japanese men with different ALDH2 genotypes. J Hum Hypertens 16, 345–351 (2002). https://doi.org/10.1038/sj.jhh.1001381
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DOI: https://doi.org/10.1038/sj.jhh.1001381
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