Abstract
The physiological role of each individual STAT protein is now being examined through the study of ‘knockout’ (KO) mice, harboring a null allele for the particular gene. In contrast to other STATs deficient mice that are born alive, STAT3-deficient mice die during early embryogenesis. However, the role of STAT3 in adult tissues can be assessed by utilizing the Cre-loxP recombination system to ablate the gene in later life. Analyses of tissue-specific STAT3-deficient mice indicate that STAT3 plays a crucial role in a variety of biological functions including cell growth, suppression and induction of apoptosis, and cell motility.
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Acknowledgements
I thank Dr K Takeda for preparing the Figures, and T Aoki for excellent secretarial assistance. This work was in part supported by grants from the Ministry of Education of Japan.
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Akira, S. Roles of STAT3 defined by tissue-specific gene targeting. Oncogene 19, 2607–2611 (2000). https://doi.org/10.1038/sj.onc.1203478
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DOI: https://doi.org/10.1038/sj.onc.1203478
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