Abstract
Large scale gene expression profiling was carried out on laser capture microdissected (LCM) tumor and normal oral epithelial cells and analysed on high-density oligonucleotide microarrays. About 600 genes were found to be oral cancer associated. These oral cancer associated genes include oncogenes, tumor suppressors, transcription factors, xenobiotic enzymes, metastatic proteins, differentiation markers, and genes that have not been implicated in oral cancer. The database created provides a verifiable global profile of gene expression during oral carcinogenesis, revealing the potential role of known genes as well as genes that have not been previously implicated in oral cancer.
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Acknowledgements
The work is supported by the National Institute of Dental and Craniofacial Research (NIDCR) grants P01 DE12467 (DTW Wong), P30 DE11814 (DTW Wong), R29 DE11983 (R Todd), Harvard University William F. Milton Fund (R Todd), Oral & Maxillofacial Surgery Foundation (H Ohyama and R Todd), and China Site Key Basic Research Program Grant G199805123 (X Zhang). H Ohyama is supported by the Scholar in Medicine Fellowship, Harvard Medical School.
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Alevizos, I., Mahadevappa, M., Zhang, X. et al. Oral cancer in vivo gene expression profiling assisted by laser capture microdissection and microarray analysis. Oncogene 20, 6196–6204 (2001). https://doi.org/10.1038/sj.onc.1204685
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DOI: https://doi.org/10.1038/sj.onc.1204685
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