Abstract
Studies of the response of p53-lacZ transgenic mice have uncovered an unexpected induction of endogenous acid-β-galactosidase activity following whole body irradiation. Strong induction of endogenous enzyme activity is seen in a variety of mouse strains commonly used in the production of transgenes. The induction of endogenous enzyme activity therefore complicates the analysis of p53-lacZ transgenes and may also influence the analysis of radiation responses in other lacZ-reporter mice.
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Coates, P., Lorimore, S., Rigat, B. et al. Induction of endogenous β-galactosidase by ionizing radiation complicates the analysis of p53-LacZ transgenic mice. Oncogene 20, 7096–7097 (2001). https://doi.org/10.1038/sj.onc.1204904
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DOI: https://doi.org/10.1038/sj.onc.1204904
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