This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Identification of a novel mechanism for reversal of doxorubicin-induced chemotherapy resistance by TXNIP in triple-negative breast cancer via promoting reactive oxygen-mediated DNA damage
Cell Death & Disease Open Access 12 April 2022
-
Impact of DNA double-strand breaks on pancreaticobiliary maljunction carcinogenesis
Diagnostic Pathology Open Access 09 August 2021
-
Quantification of wild-type and radiation attenuated Plasmodium falciparum sporozoite motility in human skin
Scientific Reports Open Access 17 September 2019
Access options
Subscribe to this journal
Receive 50 print issues and online access
$259.00 per year
only $5.18 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Ahnesorg P, Smith P, Jackson SP . (2006). XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell 124: 301–313.
Bassing CH, Alt FW . (2004). The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst) 3: 781–796.
Buck D, Moshous D, de Chasseval R, Ma Y, le Deist F, Cavazzana-Calvo M et al. (2006). Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV. Eur J Immunol 36: 224–235.
Deckbar D, Birraux J, Krempler A, Tchouandong L, Beucher A, Walker S et al. (2007). Chromosome breakage after G2 checkpoint release. J Cell Biol 176: 748–755.
Karanjawala ZE, Grawunder U, Hsieh CL, Lieber MR . (1999). The nonhomologous DNA end-joining pathway is important for chromosome stability in primary fibroblasts. Curr Biol 9: 1501–1504.
Löbrich M, Rief N, Kuhne M, Heckmann M, Fleckenstein J, Rube C et al. (2005). In vivo formation and repair of DNA double-strand breaks after computed tomography examinations. Proc Natl Acad Sci USA 102: 8984–8989.
Moshous D, Callebaut I, de Chasseval R, Corneo B, Cavazzana-Calvo M, Le Deist F et al. (2001). Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell 105: 177–186.
O'Driscoll M, Cerosaletti KM, Girard P-M, Dai Y, Stumm M, Kysela B et al. (2001). DNA ligase IV mutations identified in patients exhibiting development delay and immunodeficiency. Mol Cell 8: 1175–1185.
Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM . (2000). A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 10: 886–895.
Riballo E, Kuhne M, Rief N, Doherty A, Smith GC, Recio MJ et al. (2004). A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell 16: 715–724.
Taccioli GE, Rathbun G, Oltz E, Stamato T, Jeggo PA, Alt FW . (1993). Impairment of V(D)J recombination in double-strand break repair mutants. Science 260: 207–210.
Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y . (2003). Requirement of the MRN complex for ATM activation by DNA damage. EMBO J 22: 5612–5621.
Wyman C, Kanaar R . (2006). DNA double-strand break repair: all's well that ends well. Annu Rev Genet 40: 363–383.
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Jeggo, P., Löbrich, M. DNA double-strand breaks: their cellular and clinical impact?. Oncogene 26, 7717–7719 (2007). https://doi.org/10.1038/sj.onc.1210868
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.onc.1210868
This article is cited by
-
Cancer status in the Occupied Palestinian Territories: types; incidence; mortality; sex, age, and geography distribution; and possible causes
Journal of Cancer Research and Clinical Oncology (2023)
-
Identification of a novel mechanism for reversal of doxorubicin-induced chemotherapy resistance by TXNIP in triple-negative breast cancer via promoting reactive oxygen-mediated DNA damage
Cell Death & Disease (2022)
-
Impact of DNA double-strand breaks on pancreaticobiliary maljunction carcinogenesis
Diagnostic Pathology (2021)
-
spn-A/rad51 mutant exhibits enhanced genomic damage, cell death and low temperature sensitivity in somatic tissues
Chromosoma (2021)
-
Quantification of wild-type and radiation attenuated Plasmodium falciparum sporozoite motility in human skin
Scientific Reports (2019)