Abstract
WE have previously reported1 the discovery in muscle of a highly active metabolic mechanism, by the action of which the amino group and two hydrogen atoms of glutamic acid are transferred to pyruvic acid (added or of metabolic origin) with the formation of alanine (and ketoglutaric acid). This is the key to the puzzling fact that glutamic acid is transformed into succinic acid by muscle tissue without the formation of either ammonia or amide nitrogen (D. Moyle-Needham).
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References
Bull. Biol. et Med. Exper., Moscou, 3, 230 (1937). Biochimia, 2, 242 (1937).
Herbst and Engel, J. Biol Chem., 107, 505 (1934). Herbst, J Amer. Chem. Soc., 58, 2239 (1936).
Koranyi und Szent-Györgyi, Deutsch. Med. Wochenschr., No. 27 (1937).
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BRAUNSTEIN, A., KRITZMANN, M. Formation and Breakdown of Amino-acids by Inter-molecular Transfer of the Amino Group. Nature 140, 503–504 (1937). https://doi.org/10.1038/140503b0
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DOI: https://doi.org/10.1038/140503b0
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