Abstract
BEYOND a certain rate of urine flow, for man, dog, rabbit, etc., and provided the blood concentration does not exceed a concentration of about 200 mgm./100 ml., the following equation holds approximately: and has been chiefly demonstrated by the work of Addis and Drury1. The constant of this equation has been interpreted as a volume of blood per minute by Van Slyke and Peters2 and called a ‘clearance’, since it has also the dimensions of a volume. The interpretation is here particularly unsafe since a much better equation applying over the whole range of urine volume gives a constant with no such dimensions (a diffusion pressure equation).
Similar content being viewed by others
Article PDF
References
Addis and Drury, J. Biol. Chem., 55, 105 (1923).
Van Slyke and Peters, "Quant. Clin. Chemistry" (London).
Shannon, Amer. J. Physiol., 112, 405 (1935).
Shannon and Smith, J. Clin. Invest., 14, 393 (1935); Shannon, Amer. J. Physiol., 117, 206 (1936).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CONWAY, E. A Contradiction in the Present Clearance-Reabsorption Views of Urea Excretion. Nature 141, 471 (1938). https://doi.org/10.1038/141471b0
Published:
Issue Date:
DOI: https://doi.org/10.1038/141471b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.