Abstract
DURING the study of the mechanism of chroni congestive heart failure and other œdematous states it became more evident that there is need for a better understanding of the pharmacodynamics o mercurial diuretics. Investigations have been carried out with the use of radioactive mercury incorporated in a mercurial diuretic, 'Mercuhydrin' (sodium sal of methoxyoximercuripropylsuccinylurea with theo phylline, prepared in this laboratory by Messrs. H Krahnke, E. Sprengler and D. Kaestner through the courtesy of Dr. H. L. Daiell of Lakeside Laboratories Milwaukee, Wisconsin, with the use of mercury 203–205 from the A.E.C. Oak Ridge Operations), in order to observe for a period of 100–180 min. the concentration-time course of the isotope in the plasma of man after intravenous injection.
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RAY, C., THREEFOOT, S., BURCH, G. et al. Regression of a Radioactive Mercurial Diuretic from the Plasma of Man. Nature 163, 640–641 (1949). https://doi.org/10.1038/163640a0
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DOI: https://doi.org/10.1038/163640a0
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