Abstract
THE ability of the mustard compounds to induce gene mutations and chromosome re-arrangements was first detected in experiments with Drosophila melanogaster1–3. Subsequent investigators showed that this ability extends to all organisms which so far have been tested : Neurospora4, Tradescantia5, Penicillium6, barley7, bacteria8 and Vicia9. There can be little doubt that the mutagenic ability of the mustards is as general as that of X-rays. On the other hand, there is no a priori reason for assuming that mustards applied to other organisms will exhibit the same peculiarities of genetical effect which have been found in the work with Drosophila, namely, a relative shortage of large re-arrangements2, deferred action10,11, and preferential action on immature sperm12.
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AUERBACH, C., FALCONER, D. A New Mutant in the Progeny of Mice Treated with Nitrogen Mustard. Nature 163, 678–679 (1949). https://doi.org/10.1038/163678a0
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DOI: https://doi.org/10.1038/163678a0
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