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High-Dose Chemotherapy

High-dose chemotherapy followed by stem cell transplantation in patients with resistant Waldenstrom's macroglobulinemia

Bone Marrow Transplantation volume 27, pages 1027–1029 (2001)Cite this article

Abstract

Preliminary evidence suggests that high-dose chemotherapy followed by autologous or allogeneic stem cell transplantation may be effective in some patients with resistant Waldenstrom's macroglobulinemia. During the last 10 years, seven patients with Waldenstrom's macroglobulinemia have received transplants at the MD Anderson Cancer Center, four with autologous and three with allogeneic stem cells. Four patients achieved partial remission, and three patients have remained alive for at least 2 years. Our data confirm the feasibility of high-dose therapy in patients with macroglobulinemia and support the need for prospective studies of this modality in patients with chemosensitive disease. Bone Marrow Transplantation (2001) 27, 1027–1029.

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Authors and Affiliations

  1. Department of Blood and Marrow Transplantation of the University of Texas MD Anderson Cancer Center, Houston, TX, USA

    A Anagnostopoulos, R Champlin & S Giralt

  2. Department of Clinical Therapeutics, University of Athens School of Medicine, Alexandra Hospital, Athens, Greece

    MA Dimopoulos

  3. Department of Lymphoma/Myeloma of the University of Texas MD Anderson Cancer Center, Houston, TX, USA

    A Aleman, D Weber & R Alexanian

Authors
  1. A Anagnostopoulos
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  2. MA Dimopoulos
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  3. A Aleman
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  4. D Weber
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  5. R Alexanian
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  6. R Champlin
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  7. S Giralt
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Anagnostopoulos, A., Dimopoulos, M., Aleman, A. et al. High-dose chemotherapy followed by stem cell transplantation in patients with resistant Waldenstrom's macroglobulinemia. Bone Marrow Transplant 27, 1027–1029 (2001). https://doi.org/10.1038/sj.bmt.1703041

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  • DOI: https://doi.org/10.1038/sj.bmt.1703041

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