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Influence of transplantation regimen on prognostic significance of high-level minimal residual disease before allogeneic stem cell transplantation in children with ALL

Bone Marrow Transplantation volume 28, pages 1087–1089 (2001)Cite this article

Abstract

High MRD levels before transplantation in children receiving T cell-depleted unrelated grafts for relapsed ALL were associated with a 100% relapse risk. We report on two children with relapsed ALL who underwent non T cell-depleted BMT from unrelated donors. Despite a high residual tumor load pre- transplant and the occurrence of only aGVHD grade I, they are still in second complete remission 2.7 and 5.2 years after transplantation, respectively. Thus, we propose that the transplant regimens influence the prognostic significance of high MRD levels pre-BMT.

Bone Marrow Transplantation (2001) 28, 1087–1089.

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Acknowledgements

This work was supported by a grant from the FWF 13757-Med to ERP-G.

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Authors and Affiliations

  1. Children's Cancer Research Institute and St Anna Kinderspital, Vienna, Austria

    M Schneider, K Hettinger, S Matthes-Martin, M Konrad, C Peters, H Gadner & ER Panzer-Grümayer

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  1. M Schneider
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  2. K Hettinger
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  3. S Matthes-Martin
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  4. M Konrad
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  5. C Peters
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  6. H Gadner
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  7. ER Panzer-Grümayer
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Schneider, M., Hettinger, K., Matthes-Martin, S. et al. Influence of transplantation regimen on prognostic significance of high-level minimal residual disease before allogeneic stem cell transplantation in children with ALL. Bone Marrow Transplant 28, 1087–1089 (2001). https://doi.org/10.1038/sj.bmt.1703286

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