Abstract
In children, the optimal mobilization schedule for harvesting peripheral blood progenitor cells (PBPC) is an issue of continuous research. We have studied a schedule based on high and daily divided doses of G-CSF (12 μg/kg body weight twice daily) for 4 days for PBPC priming. Toxicity related to G-CSF was observed in 13 patients (23%), mainly mild bone pain and myalgia. The median CD34+cell number collected was 4.4 (0.4–35 × 106/kg body weight), with 46 patients achieving 2 × 106/kg body weight (83.6%) after a single large volume leukapheresis. In conclusion, this mobilization schedule allows safe and efficient collection of the minimum target CD34+ cell dose in most pediatric patients by only one procedure.
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Sevilla, J., González-Vicent, M., Madero, L. et al. Granulocyte colony-stimulating factor alone at 12 μg/kg twice a day for 4 days for peripheral blood progenitor cell priming in pediatric patients. Bone Marrow Transplant 30, 417–420 (2002). https://doi.org/10.1038/sj.bmt.1703662
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DOI: https://doi.org/10.1038/sj.bmt.1703662
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