Abstract
SEVERAL lines of evidence serve to establish glutamic-γ-semialdehyde as the key intermediate in the pathway of the biosynthesis of proline from either glutamic acid or ornithine1,2. Since glutamic-γ-semialdehyde spontaneously cyclizes nearly completely to Δ1-pyrroline-5-carboxylic acid2, hydrogenation of the latter becomes a key reaction in the biogenesis of proline.
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Stetten, M. R., J. Biol. Chem., 189, 499 (1951).
Vogel, H. J., and Davis, B. D., J. Amer. Chem. Soc., 74, 109 (1952).
Yura, T., and Vogel, H. J., Biochim. et Biophys. Acta, 12, 582 (1955).
Strecker, H. J., and Mela, P., Biochim. et Biophys. Acta, 17, 580 (1955).
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SMITH, M., GREENBERG, D. Characterization of an Enzyme reducing Pyrroline-5-Carboxylate to Proline. Nature 177, 1130 (1956). https://doi.org/10.1038/1771130a0
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DOI: https://doi.org/10.1038/1771130a0
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