Abstract
TRICYCLOQUINAZOLINE (I) has hitherto been prepared from indazole and copper powder1,2, from o-aminobenzaldehyde and ammonium chloride3 and from o-cyanoanilinium toluene-p-sulphonate2. We now find that it is readily formed in simple pyrolytic reactions. For example, methyl anthranilate was refluxed into a red-hot tube; a benzene solution of the resulting tar, after removal of its constituent acidic and basic fractions including methyl anthranilate, furnished 0.053 per cent of pure trieyclo-quinazoline by chromatography on alumina.
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BALDWIN, R., BUTLER, K., COOPER, F. et al. Carcinogenicity of Tricycloquinazoline. Nature 181, 838–839 (1958). https://doi.org/10.1038/181838a0
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DOI: https://doi.org/10.1038/181838a0
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