Abstract
STERNBERG and Kearns1 have reported that both γ-benzene hexachloride (γ-BHC)-resistant and susceptible houseflies can dehydrochlorinate γ-BHC to pentachlorocyclohexene (PCCH). Their evidence relied on the formation of 1-chloro-2:4-dinitro-benzene when the method of Schecter and Hornstein2 for the determination of γ-BHC was applied to flies treated with the insecticide. This method involved the reduction with zinc and acetic acid of unchanged γ-BHC and PCCH to benzene and chlorobenzene followed by nitration to form m-dinitrobenzene and 1-chloro-2:4-dinitrobenzene respectively. Bradbury and Standen3, working with a different strain of resistant and susceptible houseflies, used an isotopic dilution technique to determine any γ-PCCH present after γ-BHC treatment but failed to find the large amounts reported by Sternberg and Kearns.
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References
Sternberg, J., and Kearns, C. W., J. econ. Ent., 49, 548 (1956).
Schecter, M. S., and Hornstein, I., Anal. Chem., 24, 544 (1952).
Bradbury, F. R., and Standen, H., J. Sci. Food Agric., 9, 203 (1958).
Bridges, R. G., J. Sci. Food Agric., 9, 439 (1958).
Winteringham, F. P. W., Harrison, A., and Bridges, R. G., Analyst, 77, 19 (1952).
Bradbury, F. R., and Standen, H., Nature, 183, 983 (1959).
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BRIDGES, R. Pentachlorocyclohexene as a possible Intermediate Metabolite of Benzene Hexachloride in Houseflies. Nature 184, 1337–1338 (1959). https://doi.org/10.1038/1841337a0
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DOI: https://doi.org/10.1038/1841337a0
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