Abstract
IN the course of the studies concerning the interrelationship of leucine and norleucine1,2,3 it was observed that rats fed low protein diets supplemented with norleucine or norleucine and leucine were retarded. When the animals were killed and their livers analyzed for vitamin A content, it was found that these animals invariably stored a lower amount of vitamin A when compared with the control group of animals (Table 1). In view of the fact that the inhibition of growth was always associated with a depressed appetite, it was of considerable interest to determine whether the low liver vitamin A values were a consequence of the reduced food intake and thus low vitamin A consumption or whether they resulted from apparent ‘amino-acid imbalance’. In order to determine this a study was made in which the vitamin A intake was controlled.
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RECHCIGL, M., BERGER, S., LOOSLI, J. et al. Effect of ‘Amino-acid Imbalance’ on Growth and Vitamin A Storage in the White Rat. Nature 184, 1404 (1959). https://doi.org/10.1038/1841404a0
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DOI: https://doi.org/10.1038/1841404a0
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