Abstract
THE actinomycins (I to V)1 synthesized by Streptomyces antibioticus each possess two moles of D-valine per mole of antibiotic2; Streptomyces chrysomallus, on the other hand, forms a mixture consisting of actinomycins IV (contains 2 moles D-valine), VI (contains l mole D-valine and l mole D-alloisoleucine) and VII (contains 2 moles D-alloisoleucine)2. During an investigation concerned with the mechanism of synthesis of D-amino acids by S. antibioticus, it was observed that the addition of D-valine to a chemically-defined medium3 in which the organism was growing resulted in a marked inhibition of actinomycin synthesis (Table 1, Fig. 1). The relationship of this event to that seen in penicillin biosynthesis with D-valine4,5 prompted a further investigation of this phenomenon.
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References
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KATZ, E. Inhibition of Actinomycin Synthesis by D-Valine. Nature 184, 1666–1668 (1959). https://doi.org/10.1038/1841666a0
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DOI: https://doi.org/10.1038/1841666a0
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