Abstract
DURING a series of experiments involving radiation chimæras, it became increasingly evident that it would be necessary to consider the results in terms of immunological tolerance of the actively acquired type. At the time a cytological marker was being used for tracing donor cells in the radiation chimæras, following the technique of Ford, Hamerton, Barnes and Loutit1. It was decided to use the same marker in tracing cells injected into new-born animals in order to determine, by a direct method, to what extent chimærism is a necessary adjunct to tolerance. There is considerable circumstantial evidence that this is indeed the case2,3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Ford, C. E., Hamerton, J. L., Barnes, D. W. H., and Loutit, J. F., Nature, 177, 452 (1956).
Simonsen, M., Acta Path. Microbiol. Scand., 40, 480 (1957).
Billingham, R. E., Ann. N.Y. Acad. Sci., 78, 782 (1958).
Ford, C. E., and Hamerton, J. L., Stain Tech., 31, 247 (1956).
Billingham, R. E., and Brent, L. E., Transp. Bull., 4, 67 (1957).
Van Alten, P. J., and Fennell, R. A., J. Embryol. and Exp. Morph., 7, 459 (1960).
Isacson, P., Yale J. Biol. and Med., 32, 209 (1959).
Biggs, P. M., and Payne, L. N., Nature, 184, 1594 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DAVIES, A., DOAK, S. Fate of Homologous Adult Spleen Cells injected into New-born Mice. Nature 187, 610–611 (1960). https://doi.org/10.1038/187610b0
Issue Date:
DOI: https://doi.org/10.1038/187610b0
This article is cited by
-
Dissociated thymus and bone marrow cells: Synergism in Graft Versus Host reaction
Experientia (1973)
-
Synergism between Thymocytes and Bone Marrow Cells in a Graft versus Host Reaction
Nature (1970)
-
Donor and Host Contribution to Splenomegaly in Homologous Mouse Chimæras
Nature (1963)
-
Cytological Estimation of the Proportion of Proliferating Donor Cells during Graft-versus-Host Disease in F1 Hybrid Mice infected with Parental Spleen Cells
Nature (1962)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.