Abstract
IN experiments to probe the mechanism of transmission of sympathetic activity at the adrenal medulla we have found that acetylcholine, which is believed to be the chemical transmitter, evokes catecholamine secretion through some calcium-dependent process. Our evidence, obtained in experiments in cats' adrenal glands perfused in vivo or in vitro with Locke's solution or variations of it, may be summarized as follows.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Douglas, W. W., and Rubin, R. P., J. Physiol., 159, 24 (1961); Biochem. Pharmacol., 8, 20 (1961).
Douglas, W. W., and Rubin, R. P., J. Physiol. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DOUGLAS, W., RUBIN, R. Mechanism of Nicotinic Action at the Adrenal Medulla: Calcium as a Link in Stimulus-secretion Coupling. Nature 192, 1087–1089 (1961). https://doi.org/10.1038/1921087b0
Issue Date:
DOI: https://doi.org/10.1038/1921087b0
This article is cited by
-
New insights about non-neurogenic excitability revealed by MEA recordings from rat adrenal chromaffin cells
Pflügers Archiv - European Journal of Physiology (2023)
-
Catestatin regulates vesicular quanta through modulation of cholinergic and peptidergic (PACAPergic) stimulation in PC12 cells
Cell and Tissue Research (2019)
-
Acetylcholine nicotinic receptor subtypes in chromaffin cells
Pflügers Archiv - European Journal of Physiology (2018)
-
Regulation by L channels of Ca2+-evoked secretory responses in ouabain-treated chromaffin cells
Pflügers Archiv - European Journal of Physiology (2016)
-
Ikarisoside A inhibits acetylcholine-induced catecholamine secretion and synthesis by suppressing nicotinic acetylcholine receptor-ion channels in cultured bovine adrenal medullary cells
Naunyn-Schmiedeberg's Archives of Pharmacology (2015)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.