Abstract
THE literature concerning the induction of tumours by hormones is very extensive1–4. Œstrogens especially appeared to play an important part in hormonal carcinogenesis5. Evidence of a carcinogenic action of androgens is very scant. Horning6 observed 3 theca-cell ovarian tumours in rats and 2 adrenal cortical tumours in hamsters after long-term treatment with testosterone. Also, Kirkman7 suggested that testosterone propionate may act as a non-specific carcinogen in the hamster.
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References
Gardner, W. U., Adv. Cancer Res., 1, 173 (1953).
Kirschbaum, A., Cancer Res., 17, 432 (1957).
Bielschowsky, F., and Horning, E. S., Brit. Med. Bull., 14, 106 (1958).
Gardner, W. U., Pfeiffer, C. A., and Trentin, J. J., in The Physiopathology of Cancer, second ed., edited by Hamburger, F., and Fishman, W. H., 152 (Hoeber, New York, 1959).
Burrows, H., and Horning, E. S., Oestrogens and Neoplasia (Blackwell Scientific Publications, Oxford, 1952).
Horning, E. S., Brit. J. Cancer, 12, 414 (1958).
Kirkman, H., Acta Un. Int. Cancer, 16, 143 (1960).
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VAN NIE, R., BENEDETTI, E. & MÜHLBOCK, O. A Carcinogenic Action of Testosterone, provoking Uterine Tumours in Mice. Nature 192, 1303 (1961). https://doi.org/10.1038/1921303a0
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DOI: https://doi.org/10.1038/1921303a0
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