Abstract
ALTHOUGH many enzymes possess sulphydryl groups essential for enzymatic activity there have been, so far as is known, no reports of these or indeed of any other types of essential group necessary for the enzymatic activity of a penicillinase. Evidence is given here to show that sulphydryl groups are essential for the penicillinase activity of a strain of Aerobacter cloacae.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Smith, J. T., J. Gen. Microbiol., 30, 299 (1963).
Knox, R., and Smith, J. T., J. Gen. Microbiol., 28, 471 (1962).
McIlvaine, T. C., J. Biol. Chem., 49, 183 (1921).
Smith, J. T., and Hamilton-Miller, J. M. T., Nature, 197, 769 (1963).
Hellerman, L., Chinard, F. P., and Ramsdell, P. A., J. Amer. Chem. Soc., 63, 2551 (1941).
Morgan, E. J., and Friedmann, E., Biochem. J., 32, 733 (1938).
Friedmann, E., Marrian, D. H., and Simon-Reuss, I., Brit. J. Pharmacol., 3, 335 (1948).
Tsao, T., and Bailey, K., Biochim. Biophys. Acta, 11, 102 (1953).
Dickens, F., Biochem. J., 27, 1141 (1933).
Rapkine, L., C.R. Soc. Biol., 112, 790, 1294 (1933).
Barron, E. S. G., and Singer, J. P., J. Biol. Chem., 157, 221 (1945).
Rosner, L., J. Biol. Chem., 114, 601 (1936).
Anson, M. L., J. Gen. Physiol., 23, 321 (1940).
Dixon, M., and Webb, E. C., in Enzymes, 379 (Longmans, 1958).
Fraenkel-Conrat, H., in Methods in Enzymology, edit. by Colowick, S. P., and Kaplan, N. O., 4, 247 (Academic Press, 1957).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SMITH, J. Sulphydryl Groups Essential for the Penicillinase Activity of Aerobacter cloacae. Nature 197, 900–901 (1963). https://doi.org/10.1038/197900a0
Issue Date:
DOI: https://doi.org/10.1038/197900a0
This article is cited by
-
?-Lactamases from Actinopolyspora halophila, an extremely halophilic actinomycete
Archives of Microbiology (1986)
-
An inducible β-lactamase in a strain ofEscherichia coli
Antonie van Leeuwenhoek (1975)
-
Differences between Pencillinases from Gram-Positive and Gram-Negative Bacteria
Nature (1963)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.