Abstract
PAST work on the exposure of cells to protease has indicated either that the proteins on the outer surface of the cell do not contribute to the physiological properties of the membrane or that they are not available to enzymatic action. The external application of proteases to squid, lobster, or frog axons does not seem to alter the resting potential or the excitability of these cells1–4. Erythrocytes exposed to trypsin for up to 24 h show no change in permeability compared with normal cells5. However, external application of protease has been shown to produce injury potentials in muscle2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Nelson, P. G., J. Cell. and Comp. Physiol., 52, 127 (1958).
Tobias, J. M., J. Cell. and Comp. Physiol., 46, 183 (1955).
Tobias, J. M., J. Cell. and Comp. Physiol., 52, 89 (1958).
Tobias, J. M., J. Gen. Physiol., 43, Supp., 57 (1960).
Ballentine, R., and Parpart, A., J. Cell. and Comp. Physiol., 16, 49 (1940).
Northrop, J. H., J. Gen. Physiol., 16, 323 (1932).
Schwert, G. W., Neurath, H., Kaufman, S., and Snoke, J. E., J. Biol. Chem., 172, 221 (1948).
Lehmkuhl, D., and Sperelakis, N., Amer. J. Physiol., 205, 1213 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HOLTZMAN, D., AGIN, D. Effect of Trypsin on Resting Potential of Frog Muscle. Nature 205, 911–912 (1965). https://doi.org/10.1038/205911a0
Issue Date:
DOI: https://doi.org/10.1038/205911a0
This article is cited by
-
Potentials in mammalian skeletal muscle from collagenase-treated tissue
Experientia (1977)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.