Abstract
FOR several years we have been engaged at these laboratories in an investigation of the physical, chemical, and pharmacological properties of various mesoionic heterocyclic ring systems. In the first of these systems investigated—the sydnones (I)—we found marked central nervous system stimulation1–6.
Similar content being viewed by others
Article PDF
References
Kier, L. B., Fox, L. E., Dhawan, D., and Waters, I. W., Nature, 195, 817 (1962).
Kier, L. B., and Dhawan, D., J. Pharm. Sci., 51, 1058 (1962).
Dhawan, D., and Kier, L. B., J. Pharm. Sci., 53, 83 (1964).
Fregly, M. J., Kier, L. B., and Dhawan, D., Toxicol. and App. Pharmacol., 6, 529 (1964).
Kier, L. B., Dhawan, D., and Fregly, M. J., J. Pharm. Sci., 53, 677 (1964).
Lawson, K. D., Brey, W. S., and Kier, L. B., J. Amer. Chem. Soc., 86, 463 (1964).
Kier, L. B., Dodd, M. C., Sapko, P., and Stewart, T. G., Nature, 204, 697 (1964).
Stewart, T. G., and Kier, L. B., J. Pharm. Sci., 54, 731 (1965).
Ponzio, G., Gazz. Chim. Ital., 63, 471 (1933).
Boyer, J. H., and Canter, F. C., J. Amer. Chem. Soc., 77, 1280 (1955).
Boyer, J. H., and Hernandez, J. A., J. Amer. Chem. Soc., 78, 5124 (1956).
Hashimoto, M., and Ohta, M., Bull. Chem. Soc. Japan, 35, 766 (1962).
Farrar, W. V., J. Chem. Soc., 906 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KIER, L., AL-SHAMMA, A., CAMPBELL, D. et al. A New Class of Hypotensive Agents. Nature 210, 742 (1966). https://doi.org/10.1038/210742a0
Issue Date:
DOI: https://doi.org/10.1038/210742a0
This article is cited by
-
The reactions of arylazasydnones with S- and O-nucleophiles
Chemistry of Heterocyclic Compounds (2023)
-
3-(3-[1,2,4]triazolo)-oxatriazolium-5-olate causes vasodilatation by NO-independent activation of soluble guanylate cyclase
BMC Pharmacology (2005)
-
Multinuclear magnetic resonance study of some mesoionic oxatriazoles containing nitrogenous exocyclic groups
Chemistry of Heterocyclic Compounds (1995)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.