Abstract
The microdot is a means of concealing messages (steganography)1 that was developed by Professor Zapp and used by German spies in the Second World War to transmit secret information2. A microdot (“the enemy's masterpiece of espionage”2) was a greatly reduced photograph of a typewritten page that was pasted over a full stop in an innocuous letter2. We have taken the microdot a step further and developed a DNA-based, doubly steganographic technique for sending secret messages. A DNA-encoded message is first camouflaged within the enormous complexity of human genomic DNA and then further concealed by confining this sample to a microdot.
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Clelland, C., Risca, V. & Bancroft, C. Hiding messages in DNA microdots. Nature 399, 533–534 (1999). https://doi.org/10.1038/21092
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DOI: https://doi.org/10.1038/21092
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