Abstract
SINCE the initial observation that steroidal hormones from the adrenal cortex promote renal conservation of sodium was made some forty years ago, it has been demonstrated that aldosterone is the most potent sodium-retaining hormone produced by the adrenal cortex1,2. A marked increase in the secretion of aldosterone has been associated with nephrosis, liver cirrhosis, toxaemia of pregnancy and congestive heart failure3–5.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bartter, F. C., Metabolism, 5, 369 (1956).
Luetscher, J. A., jun., and Leiberman, A. H., Arch. Intern. Med., 102, 314 (1958).
Gaunt, R., Renzi, A. A., and Chart, J. J., J. Clin. Endocrinol. and Metabolism, 15, 621 (1955).
Laragh, J. H., Amer. J. Med., 21, 423 (1956).
Davis, J. O., Amer. J. Med., 29, 486 (1960).
Glitzer, M. S., and Steelman, S. L., Proc. Soc. Exp. Biol. and Med. (in the press).
Cragoe, E. J., jun., Woltersdorf, O. W., Bicking, J. B., Kwong, S. F., and Jones, J. H., jun. (in preparation).
Baer, J. E., Jones, C. B., and Zacchei, A. (in preparation).
Liddle, G. W., Metabolism Clin. and Exp., 10, 1021 (1961).
Wiggins, R. A., Hutchin, M. E., Carbone, J. C., and Doolan, P. D., Proc. Soc. Exp. Biol. and Med., 100, 625 (1959).
Wiggins, R. A., Hutchin, M. E., Carbone, J. C., and Doolan, P. D., Clin. Res., 7, 66 (1959).
Kagawa, C. M., Evaluation of Drug Activities: Pharmacometrics, 2, 752 (Academic Press, London, 1964).
Beyer, K. H., and Baer, J. E., in Progress in Drug Research, edit. by Jucker, E., 2, 9 (Interscience Publishers Inc., New York, 1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GLITZER, M., STEELMAN, S. N-Amidino-3,5-diamino-6-chloropyrazine-carboxamide : an Active Diuretic in the Carboxamide Series. Nature 212, 191–193 (1966). https://doi.org/10.1038/212191a0
Issue Date:
DOI: https://doi.org/10.1038/212191a0
This article is cited by
-
Effect of amiloride on the apical cell membrane cation channels of a sodium-absorbing, potassium-secreting renal epithelium
The Journal of Membrane Biology (1979)
-
Mode of action of amiloride in toad urinary bladder
The Journal of Membrane Biology (1977)
-
Studies on urinary excretion of the potassium-retaining diuretic amiloride (Desmethyl-pipazuroyl-guanidine, MK 870) in man
Pharmacologia Clinica (1969)
-
The mechanism of action of amipramizide
Pfl�gers Archiv European Journal of Physiology (1968)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.