Abstract
A calculation of the extent of the differences between homologous proteins shows that the amino-acid “mutations” are not as random as might have been thought. In fact, natural selection seems to act to favour those amino-acid substitutions that tend to maintain the original conformation of the protein.
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References
Eck, R. V., and Dayhoff, M. O., Atlas of Protein Sequence and Structure (Silver Spring, National Biomedical Research Foundation, 1966).
Fitch, W. M., J. Mol. Biol., 16, 9 (1966).
Fitch, W. M., J. Mol. Biol., 16, 17 (1966).
Cantor, C. R., and Jukes, T. H., Proc. US Nat. Acad. Sci., 56, 177 (1966).
Margoliash, E., and Schejter, A., Adv. Protein Chem., 21, 113 (1966).
Epstein, C. J., Nature, 203, 1350 (1964).
Epstein, C. J., Nature, 210, 25 (1966).
Perutz, M. F., Kendrew, J. C., and Watson, H. C., J. Mol. Biol., 13, 669 (1965).
Perutz, M. F., J. Mol. Biol., 13, 646 (1965).
Tanford, C., J. Amer. Chem. Soc., 84, 4240 (1962).
Woese, C. R., Proc. US Nat. Acad. Sci., 55, 966 (1966).
Sneath, P. H. A., J. Theoret. Biol., 12, 157 (1966).
Sokal, R. R., and Sneath, P. H. A., Principles of Numerical Taxonomy (W. N. Freeman and Co., San Francisco, 1963).
Goldberg, A. L., and Wittes, R. E., Science, 153, 420 (1966).
Nirenberg, M., Caskey, T., Marshall, R., Brimacombe, R., Kellogg, D., Doctor, B., Hatfield, D., Levin, J., Rottman, F., Pestka, S., Wilcox, M., and Anderson, F., Cold Spr. Harb. Symp. Quant. Biol., 31, 11 (1966).
Freese, E., and Yoshida, A., in Evolving Genes and Proteins (edit. by Bryson, V., and Vogel, H. J.), 377 (Academic Press, New York, 1965).
Goldstein, J., Konigsberg, W., and Hill, R. J., J. Biol. Chem., 238, 2016 (1963).
Schroeder, W. A., Shelton, J. R., Shelton, J. B., Cormick, J., and Jones, R. T., Biochemistry, 2, 992 (1963).
Hill, R. J., and Konigsberg, W., J. Biol. Chem., 237, 3151 (1962).
Braunitzer, G., and Matsuda, G., J. Biochem., 53, 262 (1963).
Anderer, F. A., Wittmann-Liebold, B., and Wittman, H. G., Z. Naturforsch., 20B, 1203 (1965).
Smith, E. L., Markland, F. S., Kasper, C. B., DeLange, R. J., Landon, M., and Evans, W. H., J. Biol. Chem., 241, 5974 (1966).
Beintema, J. J., Ribonuclease uit Rattepancreas (Groningen, 1966).
Hartley, B. S., Brown, J. R., Kauffman, D. L., and Smillie, L. B., Nature, 207, 1157 (1965).
Canfield, R., and Liu, A. K., J. Biol. Chem., 240, 1997 (1965).
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EPSTEIN, C. Non-randomness of Ammo-acid Changes in the Evolution of Homologous Proteins. Nature 215, 355–359 (1967). https://doi.org/10.1038/215355a0
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DOI: https://doi.org/10.1038/215355a0
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