Abstract
IT is generally believed that in some conditions tumour cells act antigenically, and that immunization of the host animal prevents tumour growth on subsequent challenge with virulent tumour cells. One of the most important problems in this field is to find a suitable and effective method to obtain attenuated tumour cells which still possess their antigenicity. Recently, two effective techniques were reported—the use of irradiated tumour cells1 and the use of tumour cells treated with iodoacetate2—and Ishidate3 has used nitrogen mustard N-oxide for this purpose.
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References
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Apffel, C. A., Arnason, B. G., and Peters, J. H., Nature, 209, 694 (1966).
Ishidate, M., Nature, 215, 184 (1967).
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Kröning, F., Acta Unis Intern. Cancr., 20, 855 (1964): Weisberger, A. S., and Pensky, J., Cancer Res., 18, 1301 (1958).
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FUJIWARA, M., NATATA, T. Induction of Tumour Immunity with Tumour Cells treated with Extract of Garlic (Allium sativum). Nature 216, 83–84 (1967). https://doi.org/10.1038/216083b0
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DOI: https://doi.org/10.1038/216083b0
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