Abstract
WE recently described positive direct Coombs tests in patients receiving sodium cephalothin1. Because most normal sera caused the in vitro agglutination of red cells coated with cephalothin, we concluded that some of the positive direct Coombs tests must be related to non-immune binding of a serum protein–cephalothin complex to the red cell surface. We also suggested the possibility that some of these test sera contained anti-penicillin agglutinins.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gralnick, H. R., Wright, L., and McGinniss, M., J. Amer. Med. Assoc., 199, 725 (1967).
Drug Letter II: Report of a Drug Reaction, Bull. Hopkins Hospital, 118, 352 (1966).
Rothschild, P. D., and Doty, D. B., J. Amer. Med. Assoc., 196, 372 (1966).
Grieco, M. H., Arch. Intern. Med., 119, 141 (1967).
Van Arsdale, P. P., et al., J. Amer. Med. Assoc., 185, 584 (1963).
Thiel, J. A., et al., J. Allergy, 35, 399 (1964).
Levine, B. B., et al., JCI, 45, 1895 (1966).
Ley, A. B., et al., Science, 127, 1118 (1958).
Marcuse, P. M., and Francis, B. J., Amer. J. Clin. Path., 34, 225 (1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GRALNICK, H., MCGINNISS, M. Immune Cross-reactivity of Penicillin and Cephalothin. Nature 216, 1026–1027 (1967). https://doi.org/10.1038/2161026a0
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1038/2161026a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.