Abstract
INCREASED vascular permeability and leucocyte emigration are important events in inflammation. In the Arthus reaction the time course of these events is distinctive, suggesting a chemical mediator different from those in other forms of inflammation1. We isolated permeability factors from the Arthus skin lesion during the period of increased vascular permeability change and then purified them2–5. Promoters of leucocyte emigration have been found in leucocytes or tissue-serum mixtures6,7 and lymph node cells8, but these substances have not yet been purified satisfactorily. The cationic protein from polymorphonuclear (PMN) lysosomes9,10 and leucotaxine11 from pleural exudates stimulate PMN emigration, but they also increase vascular permeability. This communication deals with isolation and purification of a factor which is associated with leucocyte emigration in Arthus lesions.
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YOSHIDA, K., YOSHINAGA, M. & HAYASHI, H. Leukoegresin: a Factor from Rabbit Skin associated with Leucocytic Emigration in the Arthus Reaction. Nature 218, 977–978 (1968). https://doi.org/10.1038/218977b0
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DOI: https://doi.org/10.1038/218977b0
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