Abstract
RECENT estimates1,2, based on observations of radio-isotopically labelled cholecalciferol for up to 4 days, suggest that the biological half-life of vitamin D in human plasma does not exceed 50 h. Conversely, after administration of large amounts of vitamin D, the “vitamin D activity” of plasma assayed biologically falls slowly3,4, with a half-time that may exceed 3 months (unpublished work of G. A. L. and S. W. S.).
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References
Thompson, G. R., Lewis, B., and Booth, C. C., J. Clin. Invest., 45, 94 (1966).
Avioli, L. V., Lee, S. W., McDonald, J. E., Lund, J., and DeLuca, H. F., J. Clin. Invest., 46, 983 (1967).
Warkany, J., Guest, G. M., and Grabill, F. J., J. Lab. Clin. Med., 27, 557 (1942).
Antener, I., Bull. Soc. Suisse Chem. Clin., 1 (1960).
Chen, jun., P. S., Terepka, A. R., Lane, K., and Marsh, A., Anal. Biochem., 10, 421 (1965).
Mawer, E. B., and Backhouse, J., Biochem. J. (in the press).
Mawer, E. B., and Stanbury, S. W., Biochem. J., 110, No. 4, 53 (1968).
Blunt, J. W., DeLuca, H. F., and Schnoes, H. K., Chem. Commun., 14, 801 (1968).
Avioli, L. V., Birge, S. J., and Lee, S. W., J. Clin. Endocrinol., 28, 1341 (1968).
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MAWER, E., LUMB, G. & STANBURY, S. Long Biological Half-life of Vitamin D3 and its Polar Metabolites in Human Serum. Nature 222, 482–483 (1969). https://doi.org/10.1038/222482a0
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DOI: https://doi.org/10.1038/222482a0
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