Abstract
Preparations of many different types of viruses contain defective particles which consist of viral structural proteins and a part of the viral genome. Such particles are capable of specifically interfering with the growth of homologous, standard virus and may play a major part in the evolution of viral diseases.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Fenner, F., The Biology of Animal Viruses, 1, 375 (Academic Press, New York, 1968).
Fenner, F., The Biology of Animal Viruses, 2, 475 (Academic Press, New York, 1968).
Cooper, P. D., and Bellett, A. J. D., J. Gen. Microbiol., 21, 485 (1959).
Henle, W., J. Immunol., 91, 145 (1963).
Baron, S., Medical Virology, 1, 77 (1967).
Von Magnus, P., Adv. Virus Res., 2, 59 (1954).
Ada, G. L., and Perry, B. T., J. Gen. Microbiol., 14, 623 (1958).
Lief, F. S., and Henle, W., Virology, 2, 782 (1956).
Duesberg, P. H., Proc. US Nat. Acad. Sci., 59, 930 (1968).
Mims, C. A., Brit. J. Exp. Pathol., 37, 129 (1956).
Bellett, A. J. D., and Cooper, P. D., J. Gen. Microbiol., 21, 498 (1959).
Rott, R., and Scholtissek, C., J. Gen. Microbiol., 33, 303 (1963).
Uchida, S., Watanabe, S., and Kato, M., Virology, 28, 135 (1966).
Blackstein, M. E., Stanners, C. P., and Farmilo, A. J., J. Mol. Biol., 42, 301 (1969).
Lehmann-Grube, F., Slenczka, W., and Tees, R., J. Gen. Virol., 5, 63 (1969).
Kingsbury, D. W., Portner, A., and Darlington, R. W. (in the press).
Hackett, A. J., Virology, 24, 51 (1964).
Huang, A. S., Greenawalt, J. W., and Wagner, R. R., Virology, 30, 161 (1966).
Huang, A. S., and Wagner, R. R., Virology, 30, 173 (1966).
Huang, A. S., and Wagner, R. R., J. Mol. Biol., 22, 381 (1966).
Brown, F., Martin, S. J., Cartwright, B., and Crick, J., J. Gen. Virol., 1, 479 (1967).
Hackett, A. J., Schaffer, F. L., and Madin, S. H., Virology, 31, 114 (1967).
Choppin, P. W., Virology, 39, 130 (1969).
Henle, W., and Henle, G., Amer. J. Med. Sci., 207, 705 (1949).
Traub, E., J. Exp. Med., 69, 801 (1939).
Mims, C. A., J. Pathol. Bact., 91, 395 (1966).
Wagner, R. R., and Snyder, R. M., Nature, 196, 393 (1962).
Rustigian, R., Virology, 16, 101 (1962).
Nakai, T., Shand, F. L., and Howatson, A. F., Virology, 38, 50 (1969).
Raine, C. S., Feldman, L. A., Sheppard, R. D., and Bornstein, M. B., J. Virol., 4, 169 (1969).
Horta-Barbosa, L., Fuccillo, D. A., Sever, J. L., and Zeman, W., Nature, 221, 974 (1969).
Chen, T. T., Watanabe, I., Zeman, W., and Mealy, J., Science, 163, 1193 (1969).
Katz, M., Ozanagi, S., and Koprowski, H., Nature, 222, 888 (1969).
Huang, A. S., and Wagner, R. R., Proc. US Nat. Acad. Sci., 54, 1579 (1965).
Uchida, S., Yoshiike, K., Watanabe, S., and Furuno, A., Virology, 34, 1 (1968).
Stampfer, M., Baltimore, D., and Huang, A. S., J. Virol., 4, 154 (1969).
Wagner, R. R., Levy, A. H., Snyder, R. M., Ratcliff, G. A., and Hyatt, D. F., J. Immunol., 91, 112 (1963).
Sigurdsson, B., J. Exp. Med., 78, 17 (1943).
Yoshiike, K., Virology, 34, 391 (1968).
Crick, J., Cartwright, B., and Brown, F., Arch. Ges. Virusforsch., 27, 221 (1969).
Mills, D. R., Peterson, R. L., and Spiegelman, S., Proc. US Nat. Acad. Sci., 58, 217 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HUANG, A., BALTIMORE, D. Defective Viral Particles and Viral Disease Processes. Nature 226, 325–327 (1970). https://doi.org/10.1038/226325a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/226325a0
This article is cited by
-
Peptidic defective interfering gene nanoparticles against Omicron, Delta SARS-CoV-2 variants and influenza A virus in vivo
Signal Transduction and Targeted Therapy (2022)
-
Cell culture-based production and in vivo characterization of purely clonal defective interfering influenza virus particles
BMC Biology (2021)
-
Therapeutic interfering particles exploiting viral replication and assembly mechanisms show promising performance: a modelling study
Scientific Reports (2021)
-
The evolution of cheating in viruses
Nature Communications (2021)
-
Dengue virus-free defective interfering particles have potent and broad anti-dengue virus activity
Communications Biology (2021)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.