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Molecular and cellular aspects of HTLV-1 associated leukemogenesis in vivo

Leukemia volume 17, pages 26–38 (2003)Cite this article

Abstract

Most cancers and leukemias are preceded by a prolonged period of clinical latency during which cellular, chromosomal and molecular aberrations help move normal cell towards the malignant phenotype. The problem is that premalignant cells are usually indistinguishable from their normal counterparts, thereby ruling out the possibility to investigate the events that govern early leukemogenesis in vivo. Adult T cell leukemia/lymphoma (ATLL) is a T cell malignancy that occurs after a 40–60-year period of clinical latency in about 3–5% of HTLV-1-infected individuals. ATLL cells are monoclonally expanded and harbor an integrated provirus. A persistent oligo/polyclonal expansion of HTLV-1-bearing cells has been shown to precede ATLL, supporting the fact that in ATLL tumor cells arise from a clonally expanding non-malignant cell. It is possible to isolate infected, ie preleukemic, cells during the premalignant asymptomatic phase of the infection, thus providing an exceptional system to study the mechanisms underlying human cancers. Here we review some of the consequences of HTLV-1 on its host cell in vivo, at different stages of infection.

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Acknowledgements

This work was supported by grants from the Association pour la Recherche sur le Cancer, the Fondation Contre la Leucémie, the Comités Départementaux du Rhône, de la Saone et Loire, de l’Ardèche et de la Savoie de la Ligue Nationale Contre le Cancer, and from the Programme de Recherche Fondamentale en Microbiologie et Maladies Infectieuses et Parasitaires of the French Ministry of Health. FM was the recipient of bursaries from the Ministère de l’Enseignement Supérieur et de la Recherche, from the Fondation pour la Recherche Médicale and from the Fond National pour la recherche scientifique (Belgium). ASG is supported by a grant from the Centre Léon Bérard. We thank Christiane Pinatel, Agnes Lançon, Céline Paul and Marie-Dominique Reynaud for assistance.

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  1. F Mortreux

    Present address: National Fund for Scientific Research, Faculté Universitaire des Sciences Agronomiques, Biologie Moléculaire, 13 avenue Maréchal Juin, B5030, Gembloux, Belgium

  2. F Mortreux and A-S Gabet: The first two authors contributed equally to this work

Authors and Affiliations

  1. Unité d'Oncogenèse Virale, UMR5537 CNRS-Université Claude Bernard, Centre Léon Bérard, Lyon, France

    F Mortreux, A-S Gabet & E Wattel

  2. Service d'Hématologie, Pavillon E, Hôpital Edouard Herriot, Lyon, France

    E Wattel

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Mortreux, F., Gabet, AS. & Wattel, E. Molecular and cellular aspects of HTLV-1 associated leukemogenesis in vivo. Leukemia 17, 26–38 (2003). https://doi.org/10.1038/sj.leu.2402777

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