Abstract
IN our conformational studies of nucleic acid components we have obtained X-ray diffraction photographs from specimens of the dinucleoside phosphate thymidylyl-3′,5′-deoxyadenosine (TpdA) which are similar to those obtained from certain synthetic DNA copolymers. The dinucleoside phosphate was obtained from International Enzymes Ltd as the triethylammonium salt. Some of it was dissolved in a small quantity of water between a glass slide and a coverslip resting on two thin glass fibres. Some of the material which dried out under the coverslip showed evidence of orientation when viewed between crossed polaroids. X-ray diffraction photographs were taken on a microcamera using a Hilger and Watts semi-microfocus X-ray generator and one of these is shown in Fig. 1.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Davies, D. R., and Baldwin, R. L., J. molec. Biol., 6, 251–255 (1963).
Mitsui, Y., Langridge, R., Grant, R. C., Kodama, M., Wells, R. D., Shortle, B. E., and Cantor, C. R., Nature, 228, 1166–1169 (1970).
Rosenberg, J. M., Seeman, N. C., Kim, J. J., Suddath, F. L., Nicholas, H. B., and Rich, A., Nature, 243, 150–154 (1973).
Day, R. O., Seeman, N. C., Rosenberg, J. M., and Rich, A., Proc. natn. Acad. Sci. U.S.A., 70, 849–853 (1973).
Fuller, W., Wilkins, M. H. F., Wilson, H. R., and Hamilton, L. D., J. molec. Biol., 12, 60–80 (1965).
Arnott, S., Chandrasekaran, R., Hukins, D. W. L., Smith, P. J. C., and Watts, L., J. molec. Biol. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WILSON, H. Double helix formed by the dinucleoside phosphate thymidylyl-3′,5′ -deoxyadenosine. Nature 251, 735–736 (1974). https://doi.org/10.1038/251735a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/251735a0
This article is cited by
-
Structure of thymidylyl-3′, 5′-deoxyadenosine
Nature (1976)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.