Abstract
EVIDENCE is mounting that in mice, certain specific immunological effector functions of thymus-derived (T) lymphocytes are efficient only when donors of T cells and the cells with which they interact have at least a part of the H-2 gene complex in common1–8. Examples include T helper function in vivo and in vitro1–3, cytotoxicity mediated by T cells against virus-infected4–6 or TNP-modified7 target cells in vitro, immunopathology mediated by T cells4, or protection against bacterial8 and viral infection6 in vivo. This requirement for H-2 compatibility has been studied in detail by measuring the cytotoxicity of T cells from donors immunised with either lymphocytic choriomeningitis (LCM) or ectromelia virus using target cells infected with the homologus virus.
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BLANDEN, R., DOHERTY, P., DUNLOP, M. et al. Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex. Nature 254, 269–270 (1975). https://doi.org/10.1038/254269a0
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DOI: https://doi.org/10.1038/254269a0
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