Abstract
THE regulation of contractile activity in cardiac muscle by changes in the intracellular Ca2+ concentration involves the regulatory protein system, consisting of tropomyosin and the troponin complex that is located in the I filament. Although the regulatory protein system of cardiac muscle is essentially similar in function to that of skeletal muscle, the components differ in the two tissues. Cardiac tropomyosin consists principally of α subunits, whereas the skeletal protein is composed of α and β subunits1. Troponin I, troponin C and troponin T are all specific for cardiac muscle in that they have different chemical and immunochemical properties from the corresponding skeletal muscle proteins2–4. In addition, cardiac troponin I and cardiac troponin C have been shown to have different amino acid sequences from their skeletal muscle counterparts3,5.
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References
Cummins, P., and Perry, S. V., Biochem. J., 141, 43–49 (1974).
Hirabayashi, T., and Perry, S. V., Biochim. biophys. Acta, 351, 273–389 (1973).
Grand, R. J. A., Wilkinson, J. M., and Mole, L. E., Biochem. J. (in the press).
Cole, H. A., and Perry, S. V., Biochem. J., 149, 525–533 (1975).
Van Eerd, J. P., and Takahashi, K., Biochemistry, 15, 1171–1180 (1976).
England, P., FEBS Lett., 50, 57–60 (1975).
Syska, H., Perry, S. V., and Trayler, I. P., FEBS Lett., 40, 253–257 (1974).
Neely, J. R., Leibermeister, H., Battersby, E. J., and Morgan, H. E., Am. J. Physiol., 212, 804–814 (1967).
Krebs, H. A., and Henseleit, K., Z. physicol. Chem., 210, 33–66 (1932).
Morgan, H. E., Henderson, M. J., Regen, D. M., and Park, C. R., J. Biol. Chem., 236, 253–261 (1961).
Moir, A. J. G., Wilkinson, J. M., and Perry, S. V., FEBS Lett., 42, 253–256 (1974).
Huang, T. S., Bylund, D. B., Stull, J. T., and Krebs, E. G., FEBS Lett., 42, 249–252 (1974).
Syska, H., Wilkinson, J. M., Grand, R. J. A., and Perry, S. V., Biochem. J., 153, 375–387 (1976).
Rubio, R., Bailey, C., and Villar-Palasi, C., J. Cyclic Nucleotide Res., 1, 143–150 (1975).
Perry, S. V., and Cole, H. A., Biochem. J., 141, 733–743 (1974).
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SOLARO, R., MOIR, A. & PERRY, S. Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart. Nature 262, 615–617 (1976). https://doi.org/10.1038/262615a0
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DOI: https://doi.org/10.1038/262615a0
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