Abstract
DENGUE viruses, types 1–4, are arthropod-borne flaviviruses which cause dengue shock syndrome (DSS) in humans possessing pre-infection antibody, passively acquired or derived from heterotypic infection1. Although the immuno-pathological mechanism of DSS is not fully understood, experimental studies suggest that dengue virus production is immunologically regulated. Monkeys with monotypic immunity to dengue types 1, 3 or 4 viruses, when challenged with dengue 2, had significantly higher levels of circulating virus than did similarly infected susceptible animals2. This may be attributable to the replication of virus in leukocytes. In infected monkeys, virus was frequently recovered from buffy coat cells and from lymphatic tissues3. The role of leukocytes in enhanced infection is further supported by the observation that dengue replicates readily in cultures of peripheral blood leukocytes (PBL) prepared from immune simian or human donors, but poorly or not at all in leukocytes from non-immune hosts4–6. Studies on the immunological specificity of this phenomenon have been hindered by the requirement either for expensive experimental hosts (monkeys) or for human donors with chronologically defined dengue infections. Here we describe the in vitro enhancement of dengue infection in PBL by antibody. This system provides a provisional model for DSS in young infants during primary dengue infections7,8.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Halstead, S. B. Yale J. Biol. Med. 42, 350–362 (1970).
Halstead, S. B., Shotwell, H. & Casals, J. J. infect. Dis. 128, 15–22 (1973).
Marchette, N. J., Halstead, S. B., Falkler, W. A. Jr., Stenhouse, A. C. & Nash, D. R. J. infect. Dis. 128, 23–30 (1973).
Halstead, S. B., Chow, J. & Marchette, N. J. Nature, new Biol. 243, 24–26 (1973).
Marchette, N. J., Halstead, S. B. & Chow, J. S. J. infect. Dis. 133, 274–282 (1976).
Halstead, S. B., Marchette, N. J., Chow, J. S. S. & Lolekha, S. Proc. Soc. exp. Biol. Med. 151, 136–139 (1976).
Halstead, S. B., Scanlon, J. E., Umpaivit, P. & Udomsakdi, S. Am. J. trop. Med. Hyg. 18, 987–1021 (1969).
Halstead, S. B., Nimmannitya, S. & Cohen, S. N. Yale J. Biol. Med. 42, 311–328 (1970).
Halstead, S. B., Udomsakdi, S., Simasthien, P., Singharaj, P., Sukhavachana, P. & Nisalak, A. Yale J. Biol. Med. 42, 261–275 (1970).
Halstead, S. B., Casals, J., Shotwell, H. & Palumbo, N. Am. J. trop. Med. Hyg. 22, 365–374 (1973).
Brandt, W. E., Buescher, E. L. & Hetrick, F. M., Am. J. trop. Med. Hyg. 16, 339–347 (1967).
Sartorelli, A. C., Fischer, D. S. & Downs, W. G. J. Immun. 96, 676–682 (1966).
De Madrid, A. T. & Porterfield, J. S. Bull. Wld Hlth Org. 40, 113–121 (1969).
Böyum, A. Scand. J. clin. Lab. Invest. 21 suppl. 97, 77–89 (1968).
Halstead, S. B. Am. J. trop. Med. Hyg. 23, 974–982 (1974).
Allison, A. C. Progr. med. Virol. 18, 15–31 (1974).
Simmons, J. S., St. John, J. H. & Reynolds, F. H. K. Philipp. J. Sci. 44, 1–251 (1931).
Porter, D. D. & Larsen, A. E. Prog. med. Virol. 18, 32–47 (1974).
Hawkes, R. A. & Lafferty, K. J. Virology 33, 250–261 (1967).
Kjellén, L. E. & Schlesinger, R. W. Virology 7, 236–239 (1959).
Azuma, M. Arch. ges. Virus 41, 11–19 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HALSTEAD, S., O'ROURKE, E. Antibody-enhanced dengue virus infection in primate leukocytes. Nature 265, 739–741 (1977). https://doi.org/10.1038/265739a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/265739a0
This article is cited by
-
Is new dengue vaccine efficacy data a relief or cause for concern?
npj Vaccines (2023)
-
Neutralizing Antibodies and Antibody-Dependent Enhancement in COVID-19: A Perspective
Journal of the Indian Institute of Science (2022)
-
Efficacy of a live attenuated highly pathogenic PRRSV vaccine against a NADC30-like strain challenge: implications for ADE of PRRSV
BMC Veterinary Research (2021)
-
The signal pathways and treatment of cytokine storm in COVID-19
Signal Transduction and Targeted Therapy (2021)
-
Attenuated dengue viruses are genetically more diverse than their respective wild-type parents
npj Vaccines (2021)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.