Abstract
The naturally occurring t-haplotypes of the mouse exhibit a set of peculiar genetic properties, including strong suppression of crossing over in the segment of chromosome 17 between the loci of T and H–2. Study of the genetics of mutant haplotypes suggests that the observed effects on meiosis and embryonic development may be due to an altered form of intercalary DNA (iDNA) in the relevant chromosomal region (band 17B).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bennett, D. Cell 6, 441–454 (1975).
Klein, J. Biology of the Mouse Histocompatibility-2 complex (Springer, New York, 1975).
Klein, J. & Hammerberg, C. Immun. Rev. 33, 70–104 (1977).
Sherman, M. I. & Wudl, L. R. in Concepts in Mammalian Embryogenesis (ed. Sherman, M. I.) 136–234 (MIT Press, Massachusetts, 1977).
Snell, G. D. Folia Biol. 14, 335–358 (1968).
Artzt, K. & Bennett, D. Nature 256, 545–547 (1975).
Womack, J. E. & Roderick, T. H. J. Hered. 65, 308–310 (1974).
Atwood, K. C., Gluecksohn-Waelsch, S., Yu, M. T. & Henderson, A. S. Cytogenet. Cell Genet. 17, 9–17 (1976).
Lyon, M. F. & Meredith, R. Heredity 19, 301–330 (1964).
Lyon, M. F. & Mason, I. Genet. Res. 29, 255–266 (1977).
Lyon, M. F. & Bechtol, K. B. Genet. Res. 30, 63–76 (1977).
Bechtol, K. B. & Lyon, M. F. Immunogenetics 6, 571–583 (1978).
Lyon, M. F., Jarvis, S. E., Sayers, I. & Johnson, D. R. Genet. Res. (in the press).
Dunn, L. C., Bennett, D. & Beasley, A. B. Genetics 47, 285–303 (1962).
Bennett, D., Dunn, L. C. & Artzt, K. Genetics 83, 361–372 (1976).
Artzt, K. & Bennett, D. Immunogenetics 5, 97–107 (1977).
Dunn, L. C. & Bennett, D. Proc. natn. Acad. Sci. U.S.A. 61, 570–573 (1968); Dunn, L. C. & Bennett, D. Genetics 67, 543–558 (1971).
Hammerberg, C. & Klein, J. Genet. Res. 26, 203–211 (1975).
Bennett, D. Mouse News Lett. 51, 27 (1974).
Pizarro, O. & Dunn, L. C. Transplantation 9, 207–218 (1970).
Forejt, J. Folia biol. Praha 18, 161–170 (1972); Forejt, J. & Gregorova, S. Cytogenet. Cell Genet. 19, 159–179 (1977).
Lyon, M. F. & Phillips, R. J. S. Heredity 13, 23–32 (1959).
Riley, R. & Law, C. N. Adv. Genet. 13, 57–114 (1965).
Tres, L. L. J. Cell Sci. 25, 1–15 (1977).
Eicher, E. M. & Washburn, L. Mouse News Lett. 56, 43 (1977).
Evans, E. P., Searle, A. G. & Beechey, C. V. Mouse News Lett. 57, 17 (1977).
Klein, J. & Klein, D. Genet. Res. 19, 177–179 (1972).
Forejt, J. Mouse News Lett. 59, 55 (1978).
Lyon, M. F. Mouse News Lett. 58, 44 (1978).
Hatch, F. T. & Mazrimas, J. A. in Molecular Human Cytogenetics (eds Sparkes, R. S., Comings, D. E. & Fox, C. F.) 395–414 (Academic, New York, 1977).
Stern, H. & Hotta, Y. Ann Rev. Genet. 7, 37–66 (1973); Stern, H. & Hotta, Y. Phil. Trans. R. Soc. B 277, 277–294 (1977).
Paigen, K. in Origins of Inbred Mice (ed. Morse, H. C.) 255–278 (Academic, New York, 1978).
Lewontin, R. C. & Dunn, L. C. Genetics 45, 705–722 (1960).
Evans, E. P., Breckon, G. & Ford, C. E. Cytogenetics 3, 289–294 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lyon, M., Evans, E., Jarvis, S. et al. t-Haplotypes of the mouse may involve a change in intercalary DNA. Nature 279, 38–42 (1979). https://doi.org/10.1038/279038a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/279038a0
This article is cited by
-
Characterization of GATA/GACA-related sequences on proximal chromosome 17 of the mouse
Chromosoma (1989)
-
Mapping of the Sod-2 locus into the t complex on mouse chromosome 17
Immunogenetics (1988)
-
Extent of the mouse t complex and its inversions shown by in situ hybridization
Immunogenetics (1988)
-
High frequency of unequal recombination in pseudoautosomal region shown by proviral insertion in transgenic mouse
Nature (1986)
-
Location of the t complex on mouse chromosome 17 by in situ hybridization with Tcp-1
Immunogenetics (1986)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.