Abstract
Cell membrane receptors for hormones and neurotransmitters form oligomeric complexes with GTP-regulatory proteins and inhibit the latter from reacting with GTP. Hormones and neurotransmitters act by releasing the inhibitory constraints imposed by the receptors, thus allowing the GTP-regulatory proteins to interact with and control the activity of enzymes such as adenylate cyclase. This theory may apply generally to membrane signal transduction involving surface receptors.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Rodbell, M. in Molecular Biology and Pharmacology of Cyclic Nucleotides (eds Folco, G. & Paoletti, R.) 1–12 (Elsevier, Amsterdam, 1978).
Rodbell, M., Birnbaumer, L., Pohl, S. L. & Krans, H. M. J. J. biol. Chem. 246, 1877–1882 (1971).
Rodbell, M. et al. Adv. Cyclic Nucleotide Res. 5, 3–29 (1975).
Perkins, J. P. Adv. Cyclic Nucleotide Res. 3, 1–64 (1973).
Pfeuffer, T. J. biol. Chem. 252, 7224–7234 (1977).
Pfeuffer, T. FEBS Lett. 101, 85–89 (1979).
Finkelstein, R. A. Crit. Rev. Microbiol. 2, 553–623 (1973).
Gill, D. M. Adv. Cyclic Nucleotide Res. 8, 85–118 (1977).
Johnson, G. L. & Bourne, H. R. Biochem. biophys. Res. Commun. 78, 792–798 (1977).
Fischer, J. & Sharp, G. W. G. Biochem. J. 176, 505–510 (1978).
Cassel, D. & Selinger, Z. Proc. natn. Acad. Sci. U.S.A. 74, 3307–3311 (1977).
Levinson, S. L. & Blume, A. J. J. biol. Chem. 252, 3766–3774 (1977).
Lin, M. C., Welton, A. F. & Berman, M. F. J. Cyclic Nucleotide Res. 4, 159–168 (1978).
Cassel, D. & Selinger, Z. Biochim. biophys. Acta 452, 538–551 (1978).
Gill, D. M. & Meren, R. Proc. natn. Acad. Sci. U.S.A. 75, 3050–3054 (1978).
Cassel, D. & Pfeuffer, T. Proc. natn. Acad. Sci. U.S.A. 75, 2669–2673 (1978).
Johnson, G. L., Kaslow, H. R. & Bourne, H. R. Proc. natn. Acad. Sci. U.S.A. 75, 3113–3117 (1978).
Johnson, G. L., Kaslow, H. R. & Bourne, H. R. J. biol. Chem. 253, 7120–7123 (1978).
Ross, E. M., Hewlett, A. C., Ferguson, K. M. & Gilman, A. G. J. biol. Chem. 253, 6401–6412 (1978).
Howlett, A. C., Sternweiss, P. C., Macik, B. A., Van Arsdale, P.M. & Gilman, A. G. J. biol. Chem. 254, 2287–2295 (1979).
Londos, C., Lad, P. M., Nielsen, T. B. & Rodbell, M. J. supramolec. Struct. 10, 1031–1037 (1979).
Nielsen, T., Lad, P. M., Preston, M.S. & Rodbell, M. Biochim. biophys. Acta (in the press).
Rodbell, M., Krans, H. M. J., Pohl, S. L. & Birnbaumer, L. J. biol. Chem. 246, 1872–1876 (1971).
Rodbell, M., Lin, M. C. & Salomon, Y. J. biol. Chem. 249, 59–65 (1974).
Lin, M. C., Nicosia, S., Lad, P. M. & Rodbell, M. J. biol. Chem. 252, 2790–2792 (1977).
Sonne, O., Berg, T. & Christoffersen, T. J. biol. Chem. 253, 3203–3210 (1978).
Lad, P. M., Welton, A. F. & Rodbell, M. J. biol. Chem. 252, 5942–5946 (1977).
Maguire, M. E., Van Arsdale, P. M. & Gilman, A. G. Molec. Pharmac. 12, 335–339 (1976).
Ross, E. M., Maguire, M. E., Sturgill, T. W., Biltonen, R. L. & Gilman, A. G. J. biol. Chem. 252, 5761–5775 (1977).
Williams, L. T. & Lefkowitz, R. J. J. biol. Chem. 252, 7207–7213 (1977).
Lefkowitz, R. J. & Williams, L. T. Adv. Cyclic nucleotide Res. 9, 1–17 (1978).
Sternweiss, P. C. & Gilman, A. G. J. biol. Chem. 254, 3333–3340 (1979).
Welton, A. F. et al. J. biol. Chem. 252, 5947–5950 (1977).
Limbird, L. E. & Lefkowitz, R. J. Proc. natn. Acad. Sci. U.S.A. 75, 228–232 (1978).
Maguire, M. E., Ross, E. M. & Gilman, A. G. Adv. Cyclic Nucleotide Res. 8, 1–83 (1977).
Iyengar, R. & Birnbaumer, L. Proc. natn. Acad. Sci. U.S.A. 76, 3189–3193 (1979).
Iyengar, R., Swartz, T. L. & Birnbaumer, L. J. biol. Chem. 254, 1119–1123 (1979).
Cassel, D. & Selinger, Z. Proc. natn. Acad. Sci. U.S.A. 75, 4155–4159 (1978).
Lad, P. M., Nielsen, T., Preston, M. S. & Rodbell, M. J. biol. Chem. (in the press).
Catt, K. J., Harwood, J. P., Aquilera, G. & Dufau, M. L. Nature 280, 109–116 (1979).
Goldstein, J. L., Anderson, R. G. W. & Brown, M. S. Nature 279, 679–685 (1979).
Cryer, P. E., Jarett, L. & Kipnis, D. Biochim. biophys. Acta 177, 586–590 (1969).
Harwood, J. P., Low, H. & Rodbell, M. J. biol. Chem. 248, 6239–6245 (1973).
Rodbell, M. J. biol. Chem. 250, 5826–5834 (1975).
Pairault, J. Eur. J. Biochem. 62, 323–334 (1976).
Ebert, R. & Schwabe, U. Naunyn-Schmiedebergs Archs Pharmak. 286, 297–313 (1974).
Yamamura, H., Lad, P. M. & Rodbell, M. J. biol. Chem. 252, 7964–7966 (1977).
Londos, C., Cooper, D. M. F., Schlegel, W. & Rodbell, M. Proc. natn. Acad. Sci. U.S.A. 75, 5362–5366 (1978).
Cooper, D. M. F., Schlegel, W., Lin, M. C. & Rodbell, M. J. biol. Chem. 254, 8927–8931 (1979).
Londos, C. & Wolff, J. Proc. natn. Acad. Sci. U.S.A. 74, 5482–5486 (1977).
Sabol, S. L. & Nirenberg, M. J. biol. Chem. 254, 1913–1920 (1979).
Blume, A. J., Lichtshtein, D. & Boone, G. Proc. natn. Acad. Sci. U.S.A. 76, 5626–5630 (1979).
DeCamilli, P., Macconi, D. & Spada, A. Nature 278, 252–254 (1979).
Jacobs, K. H. in Molecular Biology and Pharmacology of Cyclic Nucleotides (eds Folco, G. & Paoletti, R.) 265–278 (Elsevier, Amsterdam, 1978).
Kempner, E. S. & Schlegel, W. Analyt. Biochem. 92, 2–10 (1979).
Schlegel, W., Kempner, E. S. & Rodbell, M. J. biol. Chem. 254, 5168–5176 (1979).
Brown, E. M., Fedak, S. A., Woodward, C. J., Aurbach, G. D. & Rodbard, D. J. biol. Chem. 251, 1239–1246 (1976).
Nimmo, H. G. & Cohen, P. Adv. Cyclic Nucleotide Res. 8, 145–266 (1977).
Lin, M. C., Lin, C-S & Whitlock, J. P. Jr J. biol. Chem. 254, 4684–4688 (1979).
Bergman, R. N. & Hechter, O. J. biol. Chem. 253, 3238–3250 (1978).
Tolkovsky, A. M. & Levitzki, A. Biochemistry 17, 3795–3810 (1978).
Jacobs, S. & Cuatrecasas, P. Biochim. biophys. Acta 433, 482–495 (1976).
Hechter, O., Terana, S., Nakahara, T., Fluoret, G. & Bergman, R. N. J. biol. Chem. 253, 3219–3229 (1978).
Jard, S., Roy, C., Barth, T., Rajerson, R. & Bockaert, J. Adv. Cyclic Nucleotide Res. 5, 31–52 (1975).
Brostrom, C. O., Huang, Y., Breckenridge, B. McL. & Wolff, D. J. Proc. natn. Acad. Sci. U.S.A. 72, 64–68 (1975).
Moss, J. & Vaughan, M. Proc. natn. Acad. Sci. U.S.A. 74, 4396–4400 (1977).
Pecker, F. & Hanoune, J. J. biol. Chem. 252, 2784–2786 (1977).
Egan, J. J., Majeska, R. J. & Rodan, G. A. Biochem. biophys. Res. Commun. 80, 176–182 (1978).
Katz, M. S., Kelly, T. M., Pineyro, M. A. & Gregerman, R. I. J. Cyclic Nucleotide Res. 5, 389–407 (1978).
Edelman, G. M. Science 197, 218–226 (1976).
Insel, P. A. & Kennedy, M. J. Nature 273, 471–472 (1978).
Rudolf, S. A., Greengard, P. & Malawista, S. E. Proc. natn. Acad. Sci. U.S.A. 74, 3404–3408 (1977).
Cassel, D., Levkovitz, H. & Selinger, Z. J. Cyclic Nucleotide Res. 3, 393–406 (1977).
Cassel, D. & Selinger, Z. Biochem. biophys. Res. Commun. 77, 868–873 (1977).
Rendell, M., Rodbell, M. & Berman, M. J. biol. Chem. 252, 7909–7912 (1977).
Salomon, Y., Lin, M. C., Londos, C., Rendell, M. & Rodbell, M. J. biol. Chem. 250, 4239–4245 (1975).
Harwood, J. P., Low, H. & Rodbell, M. J. biol. Chem. 248, 6239–6245 (1973).
Eckstein, F., Cassel, D., Levkovitz, H., Lowe, M. & Selinger, Z. J. biol. Chem. 254, 9829–9834 (1979).
Cassel, D., Eckstein, F., Lowe, M. & Selinger, Z. J. biol. Chem. 254, 9835–9838 (1979).
Rubalcava, B. & Rodbell, M. J. biol. Chem. 248, 3831–3839 (1973).
Lad, P. M., Preston, S., Welton, A. F., Nielsen, T. B. & Rodbell, M. Biochim. biophys. Acta 551, 368–391 (1979).
Welton, A. F. et al. Biochim. biophys. Acta 522, 625–639 (1978).
Blackmore, P. F., Brumby, F. T., Marks, J. L. & Exton, J. H. J. biol. Chem. 253, 4851–4858 (1978).
Glossman, H., Baukal, A. & Catt, K. J. J. biol. Chem. 249, 664–666 (1974).
Walaas, O., Walaas, E., Lystad, E., Alertsen, A. R. & Horn, R. S. Molec. cell. Endocr. 16, 45–55 (1979).
Chan, T. M. & Exton, J. H. J. biol. Chem. 252, 8645–8651 (1977).
Kebabian, J. W. & Caln, D. B. Nature 277, 93–96 (1979).
Kebabian, J. W., Petzold, G. L. & Greengard, P. Proc. natn. Acad. Sci. U.S.A. 69, 2145–2149 (1972).
Spano, P. F., Govoni, S. & Trabucchi, M. Adv. Biochem. Psychopharmac. 19, 155–166 (1977).
VanInwegen, R. G., Strada, S. J. & Robison, G. A. Life Sci. 16, 1875–1876 (1975).
Puri, S. K., Cochin, J. & Volicer, L. Life Sci. 16, 759–768 (1975).
Clouet, D. H. & Iwatsubo, H. Life Sci. 17, 35–40 (1975).
Jard, S. & Bockaert, J. Physiol. Rev. 55, 489–536 (1975).
Kirk, C. S. & Hems, D. A. FEBS Lett. 47, 128–131 (1974).
Macdermot, J. et al. Proc. natn. Acad. Sci. U.S.A. 76, 1135–1139 (1979).
Gardner, J. D. A. Rev. Physiol. 41, 55–66 (1979).
Hirata, F., Strittmatter, W. J. & Axelrod, J. Proc. natn. Acad. Sci. U.S.A. 76, 368–372 (1979).
Moore, W. V. & Wolff, J. J. biol. Chem. 248, 5705–5711 (1973).
Lefkowitz, R. J., Mullikin, D., Wood, C. L., Gorder, T. B. & Mukherjee, C. J. biol. Chem. 252, 5295–5303 (1977).
Zahniser, N. R. & Molinoff, P. B. Nature 275, 453–454 (1978).
Creese, I., Usdin, T. & Snyder, S. H. Nature 278, 577–578 (1978).
Watanabe, A. M. et al. J. biol. Chem. 253, 4833–4836 (1978).
Berrie, C. P., Birdsall, N. J. M., Burgen, A. S. V. & Hulme, S. C. Biochem. biophys. Res. Commun. 87, 1000–1005 (1979).
Pert, C. B. & Taylor, D. in Endogenous and Exogenous Opiate Agonists and Antagonists (ed. Way, E. L.) (Pergamon, Oxford, in the press).
Blume, A. J., Boone, G. & Lichtshtein, D. in Modulators, Mediators, and Specifiers in Brain Function (eds Erlich, Y. H., Volavka, J., Davis, L. F. & Brunngreben, E.) 163–173 (Plenum, New York, 1979).
U'Prichard, D. C. & Snyder, S. H. J. biol. Chem. 253, 3444–3452 (1978).
Glossman, H. & Presek, P. Naunyn-Schmiedebergs Archs Pharmak. 306, 67–73 (1979).
Childers, S. R. & Snyder, S. H. Life Sci. 23, 759–762 (1978).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rodbell, M. The role of hormone receptors and GTP-regulatory proteins in membrane transduction. Nature 284, 17–22 (1980). https://doi.org/10.1038/284017a0
Issue Date:
DOI: https://doi.org/10.1038/284017a0
This article is cited by
-
Asymmetric nanoparticle may go “active” at room temperature
Science China Physics, Mechanics & Astronomy (2017)
-
Snapshot of a signalling complex
Nature (2011)
-
Heterotrimeric G‐proteins: a short history
British Journal of Pharmacology (2006)
-
Pharmacology of intracellular signalling pathways
British Journal of Pharmacology (2006)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.