Abstract
The HLA-A and -B antigens, encoded in the major histocompatibility complex, are transmembrane proteins whose carboxy termini project inwards from the cell membrane. The intracellular region of the HLA-B7 antigen is known to include two glutamine residues1. We have used guinea pig transglutaminase to show that in vitro the enzyme couples amines specifically to glutamine residues in the carboxy-terminal region of the HLA-B7 and -A2 antigens. The specificity of this reaction has an immediate practical significance, but may also have a wider biological interest.
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Pober, J., Strominger, J. Transglutaminase modifies the carboxy-terminal intracellular region of HLA-A and -B antigens. Nature 289, 819–821 (1981). https://doi.org/10.1038/289819a0
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DOI: https://doi.org/10.1038/289819a0
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