Abstract
The Harvey and Kirsten strains of murine sarcoma virus encode enzymatically and serologically related p21 src proteins which are required for virally mediated cellular transformation. The genes in each virus encoding p21 show such extensive divergence from each other that cloned probes from these genes detect distinct sets of cellular genes in the DNA from several vertebrate species. These data suggest that cellular p21 sarc genes constitute a divergent family of vertebrate genes that can regulate the growth of cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Harvey, J. J. Nature 204, 1104–1105 (1964).
Kirsten, W. H. & Mayer, L. A. J. natn. Cancer Inst. 39, 311–335 (1967).
Scher, C., Scolnick, E. M. & Siegler, D. Nature 256, 225–227 (1975).
Shih, T. Y., Weeks, M. O., Young, H. A. & Scolnick, E. M. J. Virol. 31, 546–556 (1979).
Langbeheim, H., Shih, T. Y. & Scolnick, E. M. Virology 106, 292–300 (1980).
Spector, D. H., Varmus, H. E. & Bishop, J. M. Proc. natn. Acad. Sci. U.S.A. 75, 4102–4106 (1978).
Witte, O. N., Rosenberg, N. & Baltimore, D. Nature 281, 396–398 (1979).
Sherr, C. J., Fedele, L. A., Donner, L. & Turek, L. P. J. Virol. 32, 860–875 (1979).
Collett, M. S. & Erikson, R. L. Proc. natn. Acad. Sci. U.S.A. 75, 2021–2024 (1978).
Witte, O. N., Dasgupta, A. & Baltimore, D. Nature 283, 826–831 (1980).
Van deVen, W. J. M., Reynolds, F. H. & Stephenson, J. R. Virology 101, 185–197 (1980).
Shih, T. Y., Papageorge, A. G., Stokes, P. E., Weeks, M. O. & Scolnick, E. M. Nature 287, 686–691 (1980).
Shih, T. Y. et al. J. Virol. 27, 45–55 (1978).
Chien, Y. H. et al. J. Virol. 31, 752–760 (1979).
Ellis, R. W. et al. J. Virol. 36, 408–420 (1980).
Scolnick, E. M., Vass, W. C., Howk, R. S. & Duesberg, P. H. J. Virol. 29, 964–972 (1979).
Tsuchida, N., Gilden, R. & Hatanaka, M. Proc. natn. Acad. Sci. U.S.A. 71, 4503–4507 (1974).
DeFeo, D. et al. Proc. natn. Acad. Sci. U.S.A. 78, 3328–3332 (1981).
Shih, T. Y., Weeks, M. O., Young, H. A. & Scolnick, E. M. Virology 96, 64–79 (1979).
Chang, E. H. et al. J. Virol. 35, 76–92 (1980).
Tsuchida, N. & Vesugi, S. J. Virol. 38, 720–727 (1981).
Graham, F. L. & van der Eb, A. J. Virology 52, 456–461 (1973).
Gilboa, E. et al. Cell 16, 863–874 (1979).
Chang, E. H., Ellis, R. W., Scolnick, E. M. & Lowy, D. R. Science 210, 1249–1251 (1980).
Blair, D. G., McClements, W. L., Oskarsson, M. K., Fischinger, P. J. & Vande Woude, G. F. Proc. natn. Acad. Sci. U.S.A. 77, 3504–3508 (1980).
McClements, W. L. et al. Cold Spring Harb. Symp. quant. Biol. 45 (in the press).
Young, H. A. et al. Virology 107, 89–99 (1980).
Howley, P. M., Israel, M. A., Law, M.-F. & Martin, M. A. J. biol. Chem. 254, 4876–4883 (1979).
Rasheed, S., Gardner, M. B. & Huebner, R. J. Proc. natn. Acad. Sci. U.S.A. 75, 2972–2976 (1978).
Young, H. A., Shih, T. Y., Scolnick, E. M., Rasheed, S. & Gardner, M. B. Proc. natn. Acad. Sci. U.S.A. 76, 3523–3527 (1979).
Young, H. A. et al. J. Virol. 38, 286–293 (1981).
Scolnick, E. M., Weeks, M. O., Shih, T. Y., Ruscetti, S. K. & Dexter, T. M. Molec. cell. Biol. 1, 66–74 (1981).
Nienhuis, A. W. & Bernz, E. J. New Engl. J. Med. 297, 1318–1328, 1371–1381, 1430–1436 (1977).
Lowy, D. R., Rands, E. & Scolnick, E. M. J. Virol. 26, 291–298 (1978).
McDonell, M. W., Simon, M. N. & Studier, F. W. J. molec. Biol. 110, 119–146 (1977).
Hager, G. L. et al. J. Virol. 31, 795–809 (1979).
Dhar, R., McClements, W. L., Enquist, L. W. & Vande Woude, G. F. Proc. natn. Acad. Sci. U.S.A. 77, 3937–3941 (1980).
Davis, R. W., Simon, M. & Davidson, N. Meth. Enzym. 210, 413–428 (1971).
Gross-Bellard, M., Oudet, P. & Chambon, P. Eur. J. Biochem. 36, 32–38 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ellis, R., DeFeo, D., Shih, T. et al. The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes. Nature 292, 506–511 (1981). https://doi.org/10.1038/292506a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/292506a0
This article is cited by
-
The path to the clinic: a comprehensive review on direct KRASG12C inhibitors
Journal of Experimental & Clinical Cancer Research (2022)
-
Ras-like Small GTPases Form a Large Family of Proteins in the Marine Sponge Suberites domuncula
Journal of Molecular Evolution (2007)
-
RAS oncogenes: the first 30 years
Nature Reviews Cancer (2003)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.