Abstract
The HLA–DR and related antigens are the major cell-surface glycoproteins identified so far as involved in regulation of the immune response in humans1. Here we present and discuss the sequence of cloned cDNA copies of the mRNA for the HLA–DR α-chain2. The sequence is 1,195 nucleotides long, with one open reading frame encoding a 254 amino acid primary translation product. After cleavage of the signal sequence this yields a mature polypeptide of 229 residues. Four introns have been located within the corresponding genomic sequence revealing a correlation between the protein domain structure and the genomic exon organization. Analysis of the HLA–DR α-chain amino acid sequence shows a clear homology with HLA–ABC, β2-microglobulin and immunoglobulin domains.
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Lee, J., Trowsdale, J., Travers, P. et al. Sequence of an HLA-DR α-chain cDNA clone and intron-exon organization of the corresponding gene. Nature 299, 750–752 (1982). https://doi.org/10.1038/299750a0
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DOI: https://doi.org/10.1038/299750a0
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