Abstract
Four human complement genes, which have previously been mapped between HLA-D and HLA-B on chromosome 6, have now been aligned on a 98-kilobase (kb) section of the chromosome on the basis of four overlapping cosmid clones of genomic DNA. The C2 and factor B genes, less than 2 kb apart, are about 30 kb from two C4 genes separated from each other by about 10 kb.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Francke, U. & Pelligrino, M. A. Proc. natn. Acad. Sci. U.S.A. 74, 1147–1151 (1977).
Dorf, M. E. (ed.) The Role of the Major Histocompatibility Complex in Immunobiology (Wiley, New York, 1981).
Barnstable, C. J., Jones, E. A. & Bodmer, W. F. Int. Rev. Biochem. 22, 151–226 (1979).
Aweh, Z. L., Raum, D., Yunis, E. J. & Alper, C. A. Proc. natn. Acad. Sci. U.S.A. 80, 259–263 (1983).
Porter, R. R. Molec. Biol. Med. 1, 161–168 (1983).
Reid, K. B. M. & Porter, R. R. A. Rev. Biochem. 50, 433–464 (1981).
Hall, R. E. & Colten, H. R. Proc. natn. Acad. Sci. U.S.A. 74, 1707–1710 (1977).
Weitkamp, L. R. & Lamm, L. U. Cytogenet. Cell Genet. 32, 130–143 (1982).
O'Neill, G. J., Young, S. & Dupont, B. Proc. natn. Acad. Sci. U.S.A. 75, 5165–5169 (1978).
Raum, D. et al. Am. J. hum. Genet. 31, 35–41 (1979).
Mauff, G. et al. Z. Immun. Immunobiol. 154, 115–119 (1978).
Mauff, G. et al. Immunobiology 164, 184–191 (1983).
Woods, D. E., Markham, A. F., Ricker, A. T., Goldberger, G. & Colten, H. R. Proc. natn. Acad. Sci. U.S.A. 79, 5661–5665 (1982).
Campbell, R. D. & Porter, R. R. Proc. natn. Acad. Sci. U.S.A. 80, 4464–4468 (1983).
Carroll, M. C. & Porter, R. R. Proc. natn. Acad. Sci. U.S.A. 80, 264–267 (1983).
Ogata, R. T., Shreffler, D. C., Sepich, D. S. & Lilly, S. P. Proc. natn. Acad. Sci. U.S.A. 80, 5061–5065 (1983).
Whitehead, A. S., Goldberger, G., Woods, D. E., Markham, A. F. & Colten, H. R. Proc. natn. Acad. Sci. U.S.A. 80, 5387–5391 (1983).
Bentley, D. R. & Porter, R. R. Proc. natn. Acad. Sci. U.S.A. (in the press).
Palsdottir, A., Cross, S., Edwards, J. & Carroll, M. C. Nature 306, 615–616 (1983).
Morley, B. J. & Campbell, R. D. EMBO J. (in the press).
Alper, C. A., Raum, D., Karp, S., Awdeh, Z. L. &, Yunis, E. T. Vox. Sang. 45, 62–67 (1983).
Christie, D. L. & Gagnon, J. Biochem. J. 209, 61–70 (1983).
Chakravarti, D. N., Campbell, R. D. & Gagnon, J. FEBS Lett. 154, 387–390 (1983).
Figueroa, F., Klein, D., Tewarson, S. & Klein, J. J. Immun. 129, 2089–2093 (1982).
Olaisen, B., Teisberg, P., Gedde-Dahl, T. Jr, Thorsby, E. & Jonassen, R. Immunobiology 164, 145 (1983).
Grosveld, F. G. et al. Nucleic Acids Res. 10, 6715–6732 (1982).
Grosveld, F. G., Dahl, H. M., Boer, E. D. & Flavell, R. A. Gene 13, 227–237 (1981).
Birnboim, H. C. & Doly, J. Nucleic Acids Res. 7, 1521–1534 (1979).
Southern, E. M. J. molec. Biol. 98, 503–517 (1975).
Maniatis, T., Fritsch, R. F. & Sambrook, J. (eds) Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Laboratories, New York, 1982).
Rigby, P. W. J., Dieckmann, M., Rhodes, C. & Berg, P. J. molec. Biol. 113, 237–251 (1977).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Carroll, M., Campbell, R., Bentley, D. et al. A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B. Nature 307, 237–241 (1984). https://doi.org/10.1038/307237a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/307237a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.