Abstract
The most common sites of integration of the leukosis virus (ALV) long terminal repeat (LTR) in bursal lymphomas and derivative cell lines correspond to a region encompassed by two major hypersensitive sites in the 5′ flanking region of the pre-integration, unrearranged c-myc gene. After integration of the ALV LTR, the major hypersensitive site within the avian c-myc oncogene region is within the proviral LTR, and the major hypersensitive sites normally found in uninfected cells 5′ to the first c-myc coding exon are no longer detectable.
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Schubach, W., Groudine, M. Alteration of c-myc chromatin structure by avian leukosis virus integration. Nature 307, 702–708 (1984). https://doi.org/10.1038/307702a0
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DOI: https://doi.org/10.1038/307702a0
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