Abstract
Study of the differentiation of immunoglobulin-producing B lymphocytes has been hampered by the inability to maintain homogeneous populations of precursor cells in vitro. We describe here that interleukin-3 supports the growth of freshly isolated fetal liver pre-B cells and the long-term culture of interleukin-3 dependent pre-B-cell clones that can be induced to mature into antibody secreting cells in vitro.
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Palacios, R., Henson, G., Steinmetz, M. et al. Interleukin-3 supports growth of mouse pre-B-cell clones in vitro. Nature 309, 126–131 (1984). https://doi.org/10.1038/309126a0
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DOI: https://doi.org/10.1038/309126a0
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