Abstract
The human genome contains many dispersed tandem-repetitive ‘minisatellite’ regions detected via a shared 10–15-base pair ‘core’ sequence similar to the generalized recombination signal (χ) of Escherichia coli. Many minisatellites are highly polymorphic due to allelic variation in repeat copy number in the minisatellite. A probe based on a tandem-repeat of the core sequence can detect many highly variable loci simultaneously and can provide an individual-specific DNA ‘fingerprint’ of general use in human genetic analysis.
Similar content being viewed by others
Article PDF
References
Weatherall, D. J. The New Genetics and Clinical Practice (Nuffield Provincial Hospitals Trust, London, 1982).
Botstein, D., White, R. L., Skolnick, M. & Davis, R. Am. J. hum. Genet. 32, 314–331 (1980).
Drayna, D. et al. Proc. natn. Acad. Sci. U.S.A. 81, 2836–2839 (1984).
Murray, J. M. et al. Nature 300, 69–71 (1982).
Gusella, J. F. et al. Nature 306, 234–238 (1983).
Cavanee, W. K. et al. Nature 305, 779–784 (1983).
Fearson, E. R., Vogelstein, B. & Feinberg, A. P. Nature 309, 176–178 (1984).
Koufos, A. et al. Nature 309, 170–172 (1984).
Orkin, S. H., Goldman, D. S. & Sallan, S. E. Nature 309, 172–174 (1984).
Jeffreys, A. J. Cell 18, 1–10 (1979).
Cooper, D. N. & Schmidtke, J. Hum. Genet. 66, 1–16 (1984).
Ewens, W. J., Spielman, R. S. & Harris, H. Proc. natn. Acad. Sci. U.S.A. 78, 3748–3750 (1981).
Barker, D., Schafer, M. & White, R. Cell 36, 131–138 (1984).
Wyman, A. & White, R. Proc. natn. Acad. Sci. U.S.A. 77, 6754–6758 (1980).
Bell, G. I., Selby, M. J. & Rutter, W. J. Nature 295, 31–35 (1982).
Higgs, D. R., Goodbourn, S. E. Y., Wainscoat, J. S., Clegg, J. B. & Weatherall, D. J. Nucleic Acids Res. 9, 4213–4224 (1981).
Proudfoot, N. J., Gil, A. & Maniatis, T. Cell 31, 553–563 (1982).
Goodbourn, S. E. Y., Higgs, D. R., Clegg, J. B. & Weatherall, D. J. Proc. natn. Acad. Sci. U.S.A. 80, 5022–5026 (1983).
Capon, D. J., Chen, E. Y., Levinson, A. D., Seeburg, P. H. & Goeddel, D. V. Nature 302, 33–37 (1983).
Weller, P., Jeffreys, A. J., Wilson, V. & Blanchetot, A. EMBO J. 3, 439–446 (1984).
Vieira, J. & Messing, J. Gene 19, 259–268 (1982).
Loenen, W. A. M. & Brammar, W. J. Gene 20, 249–259 (1980).
Dover, G. Nature 299, 111–117 (1982).
Morton, N. E. Outline of Genetic Epidemiology. (Karger, Basel, 1982).
Chang, L.-Y. E. & Slightom, J. L. J. molec. Biol. (in the press).
Goodman, M., Koop, B. F., Czelusniak, J., Weiss, M. & Slightom, J. L. J. molec. Biol. (in the press).
Harris, S., Barrie, P. A., Weiss, M. L. & Jeffreys, A. J. J. molec. Biol. (in the press).
White, C. T., Hardies, S. C., Hutchison, C. A. & Edgell, M. H. Nucleic Acids Res. 12, 751–766 (1984).
Smith, G. R., Kunes, S. M., Schultz, D. W., Taylor, A. & Triman, K. L. Cell 24, 429–436 (1981).
Smith, G. R. Cell 34, 709–710 (1983).
Ewens, W. J. Theor. Pop. Biol. 3, 87–112 (1972).
Ewens, W. J. Mathematical Population Genetics (Springer, Berlin, 1979).
Dretzen, G., Bellard, M., Sassone-Corri, P. & Chambon, P. Analyt. Biochem. 112, 295–298 (1981).
Maxam, A. M. & Gilbert, W. Meth. Enzym. 65, 499–560 (1980).
Southern, E. M. Meth. Enzym. 68, 152–176 (1980).
Jeffreys, A. J. et al. Cell 21, 555–564 (1980).
Messing, J. & Vieira, J. Gene 19, 269–276 (1982).
Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).
Biggin, M. D., Gibson, T. J. & Hong, H. F. Proc. natn. Acad. Sci. U.S.A. 80, 3963–3965 (1983).
Duckworth, M. L. et al. Nucleic Acids Res. 9, 1691–1706 (1981).
Renz, M. & Kurz, C. Nucleic Acids Res. 12, 3435–3444 (1984).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jeffreys, A., Wilson, V. & Thein, S. Hypervariable ‘minisatellite’ regions in human DNA. Nature 314, 67–73 (1985). https://doi.org/10.1038/314067a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/314067a0
This article is cited by
-
QTL mapping reveals key factors related to the isoflavone contents and agronomic traits of soybean (Glycine max)
BMC Plant Biology (2023)
-
Rediscovering tandem repeat variation in schizophrenia: challenges and opportunities
Translational Psychiatry (2023)
-
Novel strategy of multiple-locus variable number tandem repeats analysis for genetic fingerprinting of human
Genes & Genomics (2023)
-
From Deutsche Zeitschrift to International Journal of Legal Medicine—100 years of legal medicine through the lens of journal articles
International Journal of Legal Medicine (2023)
-
Getting the chronological age out of DNA: using insights of age-dependent DNA methylation for forensic DNA applications
Genes & Genomics (2023)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.