Abstract
Selective gene transcription is mediated in part by regulatory proteins that bind to DNA response elements. These regulatory proteins receive global information from signal-transduction events. But transcriptional regulators may also be modified in an allosteric manner by response elements themselves to generate the pattern of regulation that is appropriate to an individual gene.
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Acknowledgements
We thank W. Herr, C. Jamieson, A. Johnson, E. Levine, D. B. Starr and J. Weissman for comments on the manuscript. The authors are supported by grants from the NIH and the NSF.
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Lefstin, J., Yamamoto, K. Allosteric effects of DNA on transcriptional regulators. Nature 392, 885–888 (1998). https://doi.org/10.1038/31860
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DOI: https://doi.org/10.1038/31860
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