Abstract
Antigens that produce an antibody response in some members of a species may fail to do so in others. The response to an antigen is controlled by a gene termed the immune response (Ir) gene, which is transmitted as a single dominant trait. We have provided evidence for similar immune suppression (Is) genes which control non-responsiveness through the antigen specific suppressor T cell1–6. The non-responsiveness is also dominantly inherited and the Is genes are linked to the histocompatibility (HLA) antigen system. Here we report that the HLA-DR2 molecule from a non-responder haplotype (HLA-Dw12-DR2-DQwl) is required for the proliferative T cell response to schistosoma japonicum (Sj) antigen, as a restriction element, indicating that the HLA-DR2 is the product of the Ir gene, and that the HLA-DQwl molecule of the non-responder haplotype is important in the antigen-specific suppression of the response to this antigen, suggesting that it is the product of the Is gene. We therefore conclude that the HLA-DR and DQ molecules, which are controlled by the distinct genes in the MHC multigene family, regulate immune response and immune suppression and that the gene for HLA-DQ is epistatic to that for HLA-DR in controlling the immune response to schistosomal antigen in humans.
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References
1. Sasazuki, T. et al. J. exp. Med. 152, 297s–313s (1980). 2. Sasazuki, T., Nishimura, Y., Muto, M. & Ohta, N. Immun. Rev. 70, 51–75 (1983). 3. Sasazuki, T., Ohta, N., Kaneoka, R. & Kojima, S. J. exp. Med. 152, 314s–318s (1980). 4. Nishimura, Y. & Sasazuki, T. Nature 302, 67–69 (1983). 5. Ohta, N., Minai, M. & Sasazuki, T. J. Immun. 131, 2524–2528 (1983). 6. Matsushita, S., Muto, M., Suemura, M., Saito, Y. & Sasazuki, T. J. Immun. 138, 109–115 (1987). 7. Ohta, N., Nishimura, Y. K., luchi, M. & Sasazuki, T. Clin. exp. Immun. 49, 493–499 (1983). 8. Haynes, B. F. in Leukocyte Typing HI Vol. 1 (eds Reinherz, E. L. et al.) 3–30 (Springer, New York, 1986). 9. Koide, Y. et al. J. Immun. 129, 1061–1089 (1982). 10. Kasahara, M. et al. Immunogenetics 18, 525–536 (1983). 11. Maeda, H., Hirata, R., Juji, T. & Katagiri, M. in HLA in Asia–Oceania 1986 (ed. Aizawa, M.) 444–447 (Hokkaido University Press, Sapporo, 1986). 12. Parham, P., Barnstable, C. J. & Bodmer, W. F. /. Immun. 123, 342–349 (1979). 13. de Kretzer, T. A., Crumpton, M. J., Bodmer, J. G. & Bodmer, W. F. Eur. J. Immun. 12, 600–606 (1982). 14. Letarte, M. & Falk, J. J. Immun. 128, 217–223 (1982). 15. Sone, T. et al. J. Immun. 135, 1288–1299 (1985). 16. Dausset, J. & Cohen, D. in Histocompatibility Testing 1984 (eds Albert, E. D. et al.) 22–28 (Springer, Berlin, 1984). 17. McDevitt, H. O. J. Immunogenet. 8, 287–295 (1981). 18. Debre, P., Kapp, J. A., Dorf, M. & Benacerraf, B. /. exp. Med. 142, 1447–1453 (1975). 19. Dorf, M. E. & Benacerraf, B. Immunl. Rev. 83, 23–40 (1985). 20. Baxevanis, C. N., Ishii, N., Nagy, Z. A. & Klein, J. / exp. Med. 156, 822–833 (1982). 21. Nagy, Z. A., Baxevanis, C. N. & Klein, J. J. Immun. 130, 1498–1499 (1983). 22. Oliveira, D. B. G., Blackwell, N., Virohis, A. E. & Axelrod, R. A. Immunogenetics 22, 169–175 (1985). 23. Manual of Tissue Typing Techique 1976 (National Institutes of Health, Bethesda, 1976). 24. Chaffee, E. F., Bauman, P. M. & Shapilo, J. J. Am. J. Trap. Med. Hyg. 3, 905 (1954). 25. Wysocki, L. J. & Sato, V. L. Proc. natn. Acad. Sci. U.S.A. 75, 2844–2848 (1978). 26. Rabin, H. et al. J. Immun. 127, 1852–1856 (1981). 27. Ikeda, H. et al. Immunogenetics 19, 381–390 (1984).
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Hirayama, K., Matsushita, S., Kikuchi, I. et al. HLA-DQ is epistatic to HLA-DR in controlling the immune response to schistosomal antigen in humans. Nature 327, 426–430 (1987). https://doi.org/10.1038/327426a0
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DOI: https://doi.org/10.1038/327426a0
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